操作されたヘテロ二量体タンパク質ドメイン - Merck Patent Gesellschaft mit beschraenkter Haftung

Title:

操作されたヘテロ二量体タンパク質ドメイン

Document Type and Number:

Japanese Patent JP2009531040

Kind Code:

A

Abstract:

The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a protein-protein interaction interface containing amino acid sequence segments derived from two or more existing homologous parent domains, thereby conferring on the engineered domains assembly specificities distinct from assembly specificities of the parent domains. In particular, the engineered domains form heterodimers with one another preferentially over forming homodimers. Methods of designing and using the engineered proteins are also included.

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Inventors:

Davis Jonathan H
Houston James Stafford

Application Number:

JP2009501919A

Publication Date:

September 03, 2009

Filing Date:

March 23, 2007

Export Citation:

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Assignee:

Merck Patent Gesellschaft mit beschraenkter Haftung

International Classes:

C12N15/09; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10

Domestic Patent References:

JPH11500915A	1999-01-26
JPH11500915A	1999-01-26

Other References:

JPN6012049613; Ｊ．　Ｍｏｌ．　Ｂｉｏｌ．，　２０００，　２９５（３），　ｐｐ．６２７-３９
JPN6012049613; Ｊ．　Ｍｏｌ．　Ｂｉｏｌ．，　２０００，　２９５（３），　ｐｐ．６２７-３９

Attorney, Agent or Firm:

Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Toshio Takizawa

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