Title:
ピラゾロピリミジノン化合物を有効成分として含む、前立腺肥大症予防及び治療剤
Document Type and Number:
Japanese Patent JP2009532463
Kind Code:
A
Abstract:
The present invention relates to an agent for preventing and treating benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with BPH and a relaxant for relaxing urethral smooth muscle or prostatic smooth muscle comprising a pyrazolopyrimidinone compound as an effective ingredient. The agent in accordance with the present invention can provide nitric oxides by inhibiting the activity of PDE-5 that decomposes c-GMP, and the provided nitric oxides relax the urethral smooth muscle or the prostatic smooth muscle to lower the intraurethral pressure (IUP), thus treating BPH and LUTS associated with BPH. Furthermore, the time required for reaching a maximum blood concentration is shorter and the half-life is longer than the other PDE-5 inhibitors, thus reducing the frequency of administration. Moreover, the agent of the invention causing few side effects can be efficiently used as a safe drug.
Inventors:
Yoo, Young
Choi, Sulmin
Kung Kung
Ahn, Byung Ok
Yo, muhi
Choi, Sulmin
Kung Kung
Ahn, Byung Ok
Yo, muhi
Application Number:
JP2009504098A
Publication Date:
September 10, 2009
Filing Date:
April 04, 2006
Export Citation:
Assignee:
Don A Farm Company Limited
International Classes:
A61K31/519; A61P13/02; A61P13/08; A61P43/00; C07D487/04
Foreign References:
| US6333330B1 | 2001-12-25 | |||
| US20040029891A1 | 2004-02-12 | |||
| WO2000027848A1 | 2000-05-18 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa