Title:
5-HT2Aセロトニン受容体関連障害の治療のために有用な5-HT2Aセロトニン受容体のモジュレータとしての3-ピリジニル-ピラゾール誘導体
Document Type and Number:
Japanese Patent JP2009533442
Kind Code:
A
Abstract:
The present invention pertains to certain 3-pyridinyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggreagation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also pertains to the methods for the treatment of 5-HT2A serotonin receptor associated disorders in combination with other pharmaceutical agents administered separately or together.
Inventors:
Dosa, Peter Eye.
Tea Garden, Bradley
Tea Garden, Bradley
Application Number:
JP2009505415A
Publication Date:
September 17, 2009
Filing Date:
April 09, 2007
Export Citation:
Assignee:
Arena Pharmaceuticals, Incorporated
International Classes:
C07D401/04; A61K31/4439; A61K31/5377; A61P3/10; A61P7/02; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P25/20; A61P25/28; A61P29/00; A61P43/00; C07D487/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita