Title:
共有結合する化合物の鎮痛作用の増強と、有害な副作用の減衰と、前記化合物の乱用の予防とのための組成物及び方法
Document Type and Number:
Japanese Patent JP2009533459
Kind Code:
A
Abstract:
The invention generally relates to compositions and methods with covalently bound compounds, such as controlled substances covalently attached to a chemical moiety, and opioid antagonists or covalently bound opioid antagonists to enhance analgesic potency and/or attenuate one or more adverse effects of covalently bound compounds, including adverse side effect(s) in humans such as nausea, vomiting, dizziness, headache, sedation (somnolence), physical dependence or pruritis. This invention relates to compositions and methods for selectively enhancing the analgesic potency of a covalently bound compound and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of a covalently bound compound. The methods of the invention comprise administering to a subject an analgesic or sub-analgesic amount of a covalently bound compound and an amount of excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of a covalently bound compound and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of covalently bound compound. The invention also relates to the addition of covalently-bound opioid antagonists to the compositions containing covalently bound compounds such that if the compositions are subjected to manipulation by illicit chemists, the opioid antagonist is released effectively reducing or eliminating the euphoric effect of the covalently bound compounds.
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Inventors:
Kirk Randall Jay.
Krishnan, Zuma
James Mont Scott, Montkriev
Krishnan, Zuma
James Mont Scott, Montkriev
Application Number:
JP2009505510A
Publication Date:
September 17, 2009
Filing Date:
April 16, 2007
Export Citation:
Assignee:
Shire LRC
International Classes:
A61K47/48; A61K31/485; A61P25/04
Attorney, Agent or Firm:
Mamoru Ushiki
Masayoshi Yoshida
Shimizu Sakaematsu
Soichi Kogo
Masayoshi Yoshida
Shimizu Sakaematsu
Soichi Kogo