Title:
2-アザ-ビシクロ[3.3.0]-オクタン-3-カルボン酸誘導体の安定な医薬組成物
Document Type and Number:
Japanese Patent JP2009533461
Kind Code:
A
Abstract:
Provided are stable pharmaceutical compositions comprising from about 2.5% to about 20% of a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative by weight of the composition and at least one pharmaceutically acceptable excipient, wherein the composition preferably has a total weight of less than 100 mg. Also provided are stable pharmaceutical compositions comprising a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative in a stabilizing-effective concentration and at least one pharmaceutically acceptable excipient. Further provided are methods for improving the stability of a pharmaceutical composition and methods for treating hypertension by administering a therapeutically effective amount of the stable pharmaceutical compositions of the invention.
Inventors:
Fracobsky, Julia
Sevan, hagit
Sevan, hagit
Application Number:
JP2009505521A
Publication Date:
September 17, 2009
Filing Date:
April 19, 2007
Export Citation:
Assignee:
Teva Pharmaceutical Industries Limited
Teva Pharmaceuticals US, Inc.
Teva Pharmaceuticals US, Inc.
International Classes:
A61K31/403; A61K9/14; A61K9/20; A61K9/48; A61K31/401; A61K31/47; A61K31/5415; A61K45/00; A61K47/02; A61K47/12; A61K47/26; A61K47/32; A61K47/36; A61P9/12
Foreign References:
| WO2005094793A1 | 2005-10-13 | |||
| US20050181055A1 | 2005-08-18 | |||
| WO2005082420A1 | 2005-09-09 | |||
| US20060045911A1 | 2006-03-02 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima