Title:
グリチルレチン酸誘導体
Document Type and Number:
Japanese Patent JP2009541364
Kind Code:
A
Abstract:
The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefits from an upregulation of PPARgamma and/or a downregulation of the expression or activity of one or more specificity (Sp) proteins, such as cancer, diabetes and Huntington's disease.
More Like This:
| JP2016216364 | BLADDER SMOOTH MUSCLE HYPERCONTRACTION INHIBITOR |
| WO/2013/043778 | NOVEL BETULINIC ACID DERIVATIVES WITH ANTIVIRAL ACTIVITY |
Inventors:
Safe Stephan H.
Chinsala Paris Sudaka
M Cary Alan
Mac clindle robert
Chinsala Paris Sudaka
M Cary Alan
Mac clindle robert
Application Number:
JP2009516837A
Publication Date:
November 26, 2009
Filing Date:
June 27, 2007
Export Citation:
Assignee:
Wellington Laboratories Incorporated
The Texas A&M University System
The Texas A&M University System
International Classes:
C07J63/00; A61K31/215; A61K31/277; A61P1/00; A61P1/18; A61P3/10; A61P13/08; A61P25/14; A61P35/00; A61P43/00
Foreign References:
| GB887011B | ||||
| GB1024802B | ||||
| GB887011B | ||||
| GB1024802B |
Other References:
JPN6012041815; ＰＩＴＺＥＬＥ，Ｂ．Ｓ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ２-ｏｘｙｇｅｎａｔｅｄ ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ ｄｅｒｉｖａｔｉｖｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１７， Ｎｏ．２, 1974, ｐ．１９１-４
JPN6012041817; ＥＬＧＡＭＡＬ，Ｍ．Ｈ． ｅｔ ａｌ: 'Ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ ｄｅｒｉｖａｔｉｖｅｓ ｗｉｔｈ ｍｏｄｉｆｉｅｄ ｒｉｎｇ Ａ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６２， Ｎｏ．９, 1973, ｐ．１５５７-８
JPN6013016750; ＣＨＡＤＡＬＡＰＡＫＡ， Ｇ． ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ-ｄｅｐｅｎｄｅｎｔ ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｌａｄｄｅｒ ａｎｄ ｐａｎｃｒｅａｔｉｃ ｃａｎｃｅｒ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ ２-ｓｕｂｓｔｉｔｕｔｅｄ ｇｌｙｃｙｒｒ' Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． Ｖｏｌ．１８， Ｉｓｓ．８, 2008, ｐ．２６３３-９
JPN6012041811; ＥＬＧＡＭＡＬ，Ｍ．Ｈ． ｅｔ ａｌ: 'Ｃ-２，Ｃ-３-Ｇｌｙｃｏｌ ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．３０， Ｎｏ．２３／２４, 1974, ｐ．４０８３-７
JPN6012041813; ＣＨＩＮＴＨＡＲＬＡＰＡＬＬＩ，Ｓ． ｅｔ ａｌ．: Ｍｏｌ． Ｃａｎｃｅｒ Ｔｈｅｒ． Ｖｏｌ．６， ｎｏ．５, 20070518, ｐ．１５８８-９８
JPN6012041815; ＰＩＴＺＥＬＥ，Ｂ．Ｓ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ２-ｏｘｙｇｅｎａｔｅｄ ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ ｄｅｒｉｖａｔｉｖｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１７， Ｎｏ．２, 1974, ｐ．１９１-４
JPN6012041817; ＥＬＧＡＭＡＬ，Ｍ．Ｈ． ｅｔ ａｌ: 'Ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ ｄｅｒｉｖａｔｉｖｅｓ ｗｉｔｈ ｍｏｄｉｆｉｅｄ ｒｉｎｇ Ａ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６２， Ｎｏ．９, 1973, ｐ．１５５７-８
JPN6013016750; ＣＨＡＤＡＬＡＰＡＫＡ， Ｇ． ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ-ｄｅｐｅｎｄｅｎｔ ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｌａｄｄｅｒ ａｎｄ ｐａｎｃｒｅａｔｉｃ ｃａｎｃｅｒ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ ２-ｓｕｂｓｔｉｔｕｔｅｄ ｇｌｙｃｙｒｒ' Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． Ｖｏｌ．１８， Ｉｓｓ．８, 2008, ｐ．２６３３-９
JPN6012041817; ＥＬＧＡＭＡＬ，Ｍ．Ｈ． ｅｔ ａｌ: 'Ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ ｄｅｒｉｖａｔｉｖｅｓ ｗｉｔｈ ｍｏｄｉｆｉｅｄ ｒｉｎｇ Ａ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６２， Ｎｏ．９, 1973, ｐ．１５５７-８
JPN6013016750; ＣＨＡＤＡＬＡＰＡＫＡ， Ｇ． ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ-ｄｅｐｅｎｄｅｎｔ ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｌａｄｄｅｒ ａｎｄ ｐａｎｃｒｅａｔｉｃ ｃａｎｃｅｒ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ ２-ｓｕｂｓｔｉｔｕｔｅｄ ｇｌｙｃｙｒｒ' Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． Ｖｏｌ．１８， Ｉｓｓ．８, 2008, ｐ．２６３３-９
JPN6012041811; ＥＬＧＡＭＡＬ，Ｍ．Ｈ． ｅｔ ａｌ: 'Ｃ-２，Ｃ-３-Ｇｌｙｃｏｌ ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．３０， Ｎｏ．２３／２４, 1974, ｐ．４０８３-７
JPN6012041813; ＣＨＩＮＴＨＡＲＬＡＰＡＬＬＩ，Ｓ． ｅｔ ａｌ．: Ｍｏｌ． Ｃａｎｃｅｒ Ｔｈｅｒ． Ｖｏｌ．６， ｎｏ．５, 20070518, ｐ．１５８８-９８
JPN6012041815; ＰＩＴＺＥＬＥ，Ｂ．Ｓ．: 'Ｓｙｎｔｈｅｓｉｓ ｏｆ ２-ｏｘｙｇｅｎａｔｅｄ ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ ｄｅｒｉｖａｔｉｖｅｓ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１７， Ｎｏ．２, 1974, ｐ．１９１-４
JPN6012041817; ＥＬＧＡＭＡＬ，Ｍ．Ｈ． ｅｔ ａｌ: 'Ｇｌｙｃｙｒｒｈｅｔｉｃ ａｃｉｄ ｄｅｒｉｖａｔｉｖｅｓ ｗｉｔｈ ｍｏｄｉｆｉｅｄ ｒｉｎｇ Ａ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｓｃｉｅｎｃｅｓ Ｖｏｌ．６２， Ｎｏ．９, 1973, ｐ．１５５７-８
JPN6013016750; ＣＨＡＤＡＬＡＰＡＫＡ， Ｇ． ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ-ｄｅｐｅｎｄｅｎｔ ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｌａｄｄｅｒ ａｎｄ ｐａｎｃｒｅａｔｉｃ ｃａｎｃｅｒ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ ２-ｓｕｂｓｔｉｔｕｔｅｄ ｇｌｙｃｙｒｒ' Ｂｉｏｏｒｇ． Ｍｅｄ． Ｃｈｅｍ． Ｌｅｔｔ． Ｖｏｌ．１８， Ｉｓｓ．８, 2008, ｐ．２６３３-９
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki