Title:
6,7-ジアルコキシキナゾリン、6,7-ジアルコキシフタラジンおよび6,7-ジアルコキシイソキノリンの(3-アリール-ピペラジン-1-イル)、(2-アリール-モルホリン-4-イル)および(2-アリール-チオモルホリン-4-イル)誘導体
Document Type and Number:
Japanese Patent JP2009542732
Kind Code:
A
Abstract:
This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides a process for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
Inventors:
Koehler Yang
Application Number:
JP2009518719A
Publication Date:
December 03, 2009
Filing Date:
July 10, 2007
Export Citation:
Assignee:
Her Lundbeck Actiezer Scabet
International Classes:
C07D403/04; A61K31/506; A61K31/5377; A61K31/541; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P31/18; A61P35/00; A61P43/00; C07D413/04; C07D417/04; C07B61/00
Domestic Patent References:
| JP2009529052A | 2009-08-13 | |||
| JP2009529060A | 2009-08-13 | |||
| JP2009524637A | 2009-07-02 |
Foreign References:
| WO2006011040A1 | 2006-02-02 | |||
| WO2006028957A1 | 2006-03-16 | |||
| WO2005082883A2 | 2005-09-09 |
Attorney, Agent or Firm:
Mitsufumi Esaki
Okumura Yoshimichi
Blacksmith
Okumura Yoshimichi
Blacksmith