Title:
ヒト成長および分化因子GDF-5
Document Type and Number:
Japanese Patent JP2009543566
Kind Code:
A
Abstract:
This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under physiological conditions. Said compositions of one or more precursor proteins of growth factors of the GDF family provoke morphogenic effects such as for example growth, differentiation, protection and regeneration of a variety of tissues and organs, e.g. bone, cartilage, tendons, ligaments, nerves and skin. The invention can be advantageously used for the healing of tissue-destructive injuries and for the prevention or therapy of degenerative disorders.
Inventors:
Jens Paul
Frank Pregger
Frank Pregger
Application Number:
JP2009519863A
Publication Date:
December 10, 2009
Filing Date:
July 17, 2007
Export Citation:
Assignee:
Biopharm Gesellschaft Tsa Biotechinologischen Entwick Lung von Pharmaka Mbeher
International Classes:
C12N15/09; A61K38/22; A61K38/46; A61P17/14; A61P19/10; A61P21/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C07K14/475; C12P21/02
Domestic Patent References:
| JP2004525930A | 2004-08-26 | |||
| JPH11509097A | 1999-08-17 | |||
| JP2001505097A | 2001-04-17 | |||
| JP2003506086A | 2003-02-18 | |||
| JPH08505548A | 1996-06-18 |
Foreign References:
| WO2004084965A2 | 2004-10-07 | |||
| WO2004024890A2 | 2004-03-25 | |||
| WO1996033215A1 | 1996-10-24 | |||
| WO2005093071A1 | 2005-10-06 |
Other References:
JPN6012043991; ＲＡＴＴＥＮＨＯＬＬ， Ａ． ｅｔ ａｌ．: Ｊ． Ｍｏｌ． Ｂｉｏｌ． Ｖｏｌ．３０５, 2001, ｐｐ．５２３-５３３
JPN6012043994; ＥＤＥＲ， Ｊ． ａｎｄ ＦＥＲＳＨＴ， Ａ．Ｒ．: Ｍｏｌ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．１６， Ｎｏ．４, 1995, ｐｐ．６０９-６１４
JPN6012043996; ＮＯＶＹ， Ｒ． ｅｔ ａｌ．: ｉｎＮｏｖａｔｉｏｎｓ Ｎｏ．１２, 2001, ｐｐ．１-３
JPN6013055256; ＫＲＩＥＧＬＳＴＥＩＮ， Ｋ． ｅｔ ａｌ．: Ｊ． Ｎｅｕｒｏｓｃｉ． Ｒｅｓ． Ｖｏｌ．４２, 1995, ｐｐ．７２４-７３２
JPN6013055257; ＳＵＬＬＩＶＡＮ， Ａ．Ｍ． ｅｔ ａｌ．: Ｎｅｕｒｏｓｃｉ． Ｌｅｔｔ． Ｖｏｌ．２３３, 1997, ｐｐ．７３-７６
JPN6013055258; ＳＵＬＬＩＶＡＮ， Ａ．Ｍ． ｅｔ ａｌ．: Ｅｕｒ． Ｊ． Ｎｅｕｒｏｓｃｉ． Ｖｏｌ．１０, 1998, ｐｐ．３６８１-３６８８
JPN6012043989; ＪＩＮ， Ｈ．-Ｊ． ｅｔ ａｌ．: Ｐｒｏｔｅｉｎ Ｅｘｐｒ． Ｐｕｒｉｆ． Ｖｏｌ．３５, 2004, ｐｐ．１-１０
JPN6012043990; ＡＳＨＲＡＦ， Ｓ． ｅｔ ａｌ．: Ｐｒｏｔｅｉｎ Ｅｘｐｒ． Ｐｕｒｉｆ． Ｖｏｌ．３３, 2004, ｐｐ．２３８-２４５
JPN5009009981; ＳＣＨＭＩＤＴ Ｆ Ｒ: ＡＰＰＬＩＥＤ ＭＩＣＲＯＢＩＯＬＯＧＹ ＡＮＤ ＢＩＯＴＥＣＨＮＯＬＯＧＹ Ｖ６５ Ｎ４, 200409, Ｐ３６３-３７２
JPN6014037541; ＣＯＮＳＴＡＭ， Ｄ．Ｂ． ｅｔ ａｌ．: Ｊ． Ｃｅｌｌ Ｂｉｏｌ． Ｖｏｌ．１３４, 1996, ｐｐ．１８１-１９１
JPN6012043994; ＥＤＥＲ， Ｊ． ａｎｄ ＦＥＲＳＨＴ， Ａ．Ｒ．: Ｍｏｌ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．１６， Ｎｏ．４, 1995, ｐｐ．６０９-６１４
JPN6012043996; ＮＯＶＹ， Ｒ． ｅｔ ａｌ．: ｉｎＮｏｖａｔｉｏｎｓ Ｎｏ．１２, 2001, ｐｐ．１-３
JPN6013055256; ＫＲＩＥＧＬＳＴＥＩＮ， Ｋ． ｅｔ ａｌ．: Ｊ． Ｎｅｕｒｏｓｃｉ． Ｒｅｓ． Ｖｏｌ．４２, 1995, ｐｐ．７２４-７３２
JPN6013055257; ＳＵＬＬＩＶＡＮ， Ａ．Ｍ． ｅｔ ａｌ．: Ｎｅｕｒｏｓｃｉ． Ｌｅｔｔ． Ｖｏｌ．２３３, 1997, ｐｐ．７３-７６
JPN6013055258; ＳＵＬＬＩＶＡＮ， Ａ．Ｍ． ｅｔ ａｌ．: Ｅｕｒ． Ｊ． Ｎｅｕｒｏｓｃｉ． Ｖｏｌ．１０, 1998, ｐｐ．３６８１-３６８８
JPN6012043989; ＪＩＮ， Ｈ．-Ｊ． ｅｔ ａｌ．: Ｐｒｏｔｅｉｎ Ｅｘｐｒ． Ｐｕｒｉｆ． Ｖｏｌ．３５, 2004, ｐｐ．１-１０
JPN6012043990; ＡＳＨＲＡＦ， Ｓ． ｅｔ ａｌ．: Ｐｒｏｔｅｉｎ Ｅｘｐｒ． Ｐｕｒｉｆ． Ｖｏｌ．３３, 2004, ｐｐ．２３８-２４５
JPN5009009981; ＳＣＨＭＩＤＴ Ｆ Ｒ: ＡＰＰＬＩＥＤ ＭＩＣＲＯＢＩＯＬＯＧＹ ＡＮＤ ＢＩＯＴＥＣＨＮＯＬＯＧＹ Ｖ６５ Ｎ４, 200409, Ｐ３６３-３７２
JPN6014037541; ＣＯＮＳＴＡＭ， Ｄ．Ｂ． ｅｔ ａｌ．: Ｊ． Ｃｅｌｌ Ｂｉｏｌ． Ｖｏｌ．１３４, 1996, ｐｐ．１８１-１９１
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro