Title:
Toll様レセプター4の機能障害およびその生物学的応用
Document Type and Number:
Japanese Patent JP2009543570
Kind Code:
A
Abstract:
The present invention relates to an in vitro method of assessing the sensitivity of a subject to a treatment of cancer, which method comprises detecting the presence of a mutated Toll Like Receptor 4 (TLR4) nucleic acid or an abnormal TLR4 protein expression or activity in a sample from the subject, the presence of said mutated TLR4 nucleic acid or abnormal TLR4 expression or activity being indicative of a resistance to said treatment. The detection of the presence of a mutated Toll Like Receptor 4 (TLR4) nucleic acid or an abnormal TLR4 protein expression or activity in a sample from a subject is also indicative of a predisposition to a cancer in the subject.
More Like This:
Inventors:
Abt, Lionel
Kramer, Juido
Zivogel, Laurence
Kramer, Juido
Zivogel, Laurence
Application Number:
JP2009519976A
Publication Date:
December 10, 2009
Filing Date:
July 17, 2007
Export Citation:
Assignee:
INSTITUT GUSTAVE ROUSSY
International Classes:
C12Q1/68; A61K31/7048; A61K31/7105; A61K35/28; A61K45/00; A61P35/00; C12N15/09; G01N33/53
Other References:
JPN6012059518; Ｂｉｏｔｈｅｒａｐｙ，Ｖｏｌ．１５，Ｎｏ．３（２００１）ｐ．３６９-３７３
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito