Title:
目の障害の予防および処置のための内皮分化遺伝子ファミリー3(EDG-3、S1P3)レセプターのアンタゴニスト
Document Type and Number:
Japanese Patent JP2009544734
Kind Code:
A
Abstract:
Antagonists of S1P3 (Edg-3) receptors are provided for attenuation of Smad signaling in a method of down-regulation of receptor signaling and downstream decreased production of connective tissue growth factor in ocular disorders involving CTGF accumulation. Ocular disorders involving inappropriate CTGF accumulation include ocular hypertension, glaucoma, glaucomatous retinopathy, optic neuropathy, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and ocular wound healing, for example. Such disorders are treated by administering antagonists of the present invention.
More Like This:
Inventors:
Frenoir, Debra El.
Shepherd, Alan Earl.
Bread, iok-ho
Shepherd, Alan Earl.
Bread, iok-ho
Application Number:
JP2009521989A
Publication Date:
December 17, 2009
Filing Date:
July 25, 2007
Export Citation:
Assignee:
Archon Research, Limited
International Classes:
A61K45/00; A61K31/133; A61K31/167; A61K31/426; A61K31/54; A61K38/00; A61K39/395; A61P27/02; A61P27/06
Domestic Patent References:
| JP2005247691A | 2005-09-15 | |||
| JP2002332278A | 2002-11-22 |
Foreign References:
| WO1995019779A1 | 1995-07-27 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita