Title:
ビタミンD化合物及び追加の治療薬の投与を含む癌の治療方法
Document Type and Number:
Japanese Patent JP2010501576
Kind Code:
A
Abstract:
Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a vitamin D compound in combination with at least one additional therapeutic agent, such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising vitamin D compounds and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid, e.g., corticosteroid or more specifically, a glucocorticoid.
Inventors:
Alan H. Auerbakow
Arie S. Berludegrun
Arie S. Berludegrun
Application Number:
JP2009525648A
Publication Date:
January 21, 2010
Filing Date:
August 23, 2007
Export Citation:
Assignee:
Kuogal Biotechnology, Inc.
International Classes:
A61K31/045; A61K31/136; A61K31/167; A61K31/337; A61K31/573; A61K38/00; A61K38/04; A61P35/00; A61P43/00
Other References:
JPN7012004504; Ｍａｓｕｄａ Ｓ ｅｔ ａｌ．: 'Ｐｒｏｍｉｓｅ ｏｆ ｖｉｔａｍｉｎ Ｄ ａｎａｌｏｇｕｅｓ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｈｙｐｅｒｐｒｏｌｉｆｅｒａｔｉｖｅ ｃｏｎｄｉｔｉｏｎｓ．' Ｍｏｌ Ｃａｎｃｅｒ Ｔｈｅｒ． ５（４）, 200604, ７９７-８０８
JPN6012057652; Ｆｌａｉｇ ＴＷ: 'Ａ ｐｈａｓｅ ＩＩ ｔｒｉａｌ ｏｆ ｄｅｘａｍｅｔｈａｓｏｎｅ， ｖｉｔａｍｉｎ Ｄ， ａｎｄ ｃａｒｂｏｐｌａｔｉｎ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｏｒｍｏｎｅ-ｒｅｆｒａｃｔｏｒｙ ｐｒ' Ｃａｎｃｅｒ １０７（２）, 20060715, ２６６-７４
JPN6012057656; Ｂｅｅｒ ＴＭ ｅｔ ａｌ．: 'Ｗｅｅｋｌｙ ｈｉｇｈ-ｄｏｓｅ ｃａｌｃｉｔｒｉｏｌ ａｎｄ ｄｏｃｅｔａｘｅｌ ｉｎ ｍｅｔａｓｔａｔｉｃ ａｎｄｒｏｇｅｎ-ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ．' Ｊ Ｃｌｉｎ Ｏｎｃｏｌ ２１（１）, 200311, １２３-８
JPN6012057659; Ｔｒｕｍｐ ＤＬ ｅｔ ａｌ．: 'Ｐｈａｓｅ ＩＩ ｔｒｉａｌ ｏｆ ｈｉｇｈ-ｄｏｓｅ， ｉｎｔｅｒｍｉｔｔｅｎｔ ｃａｌｃｉｔｒｉｏｌ （１，２５ ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ Ｄ３） ａｎｄ ｄｅｘａｍｅｔｈａｓｏｎｅ ｉｎ' Ｃａｎｃｅｒ １０６（１０）, 20060515, ２１３６-４２
JPN7012004505; Ｐｅｅｈｌ ＤＭ: 'Ｐｒｅｃｌｉｎｉｃａｌ ａｃｔｉｖｉｔｙ ｏｆ ｋｅｔｏｃｏｎａｚｏｌｅ ｉｎ ｃｏｍｂｉｎａｔｉｏｎ ｗｉｔｈ ｃａｌｃｉｔｒｉｏｌ ｏｒ ｔｈｅ ｖｉｔａｍｉｎ Ｄ ａｎａｌｏｇｕｅ ＥＢ １０８' Ｊ Ｕｒｏｌ． １６８（４ Ｐｔ １）, 200210, １５８３-８
JPN5009015872; Ｋｏｓｈｉｚｕｋａ Ｋ: 'Ｃｏｍｂｉｎｅｄ ｅｆｆｅｃｔ ｏｆ ｖｉｔａｍｉｎ Ｄ３ ａｎａｌｏｇｓ ａｎｄ ｐａｃｌｉｔａｘｅｌ ｏｎ ｔｈｅ ｇｒｏｗｔｈ ｏｆ ＭＣＦ-７ ｂｒｅａｓｔ ｃａｎｃｅｒ ｃｅｌｌｓ ｉｎ ｖ' Ｂｒｅａｓｔ Ｃａｎｃｅｒ Ｒｅｓ Ｔｒｅａｔ． ５３（２）, 199901, １１３-１２０
JPN7012004506; Ｃｈｒｉｓｔｅｎｓｅｎ ＧＬ ｅｔ ａｌ．: 'Ｓｅｑｕｅｎｔｉａｌ ｖｅｒｓｕｓ ｃｏｍｂｉｎｅｄ ｔｒｅａｔｍｅｎｔ ｏｆ ｈｕｍａｎ ｂｒｅａｓｔ ｃａｎｃｅｒ ｃｅｌｌｓ ｗｉｔｈ ａｎｔｉｅｓｔｒｏｇｅｎｓ ａｎｄ ｔｈｅ ｖｉｔａｍｉｎ' Ｂｒｅａｓｔ Ｃａｎｃｅｒ Ｒｅｓ Ｔｒｅａｔ． ８５（１）, 200405, ５３-６３
JPN6012057667; Ｖｉｎｋ-ｖａｎ Ｗｉｊｎｇａａｒｄｅｎ Ｔ ｅｔ ａｌ．: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｒｅａｓｔ ｃａｎｃｅｒ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ ｃｏｍｂｉｎｅｄ ｔｒｅａｔｍｅｎｔ ｗｉｔｈ ｖｉｔａｍｉｎ Ｄ３ ａｎａｌｏｇｕｅｓ ａｎｄ ｔａｍｏｘｉｆｅ' Ｃａｎｃｅｒ Ｒｅｓ． ５４（２１）, 199411, ５７１１-７
JPN6012057670; Ｃｏｌｓｔｏｎ ＫＷ ｅｔ ａｌ．: 'Ｍｅｃｈａｎｉｓｍｓ ｉｍｐｌｉｃａｔｅｄ ｉｎ ｔｈｅ ｇｒｏｗｔｈ ｒｅｇｕｌａｔｏｒｙ ｅｆｆｅｃｔｓ ｏｆ ｖｉｔａｍｉｎ Ｄ ｉｎ ｂｒｅａｓｔ ｃａｎｃｅｒ．' Ｅｎｄｏｃｒ Ｒｅｌａｔ Ｃａｎｃｅｒ ９（１）, 200203, ４５-５９
JPN6012057673; Ｄａｎｉｌｅｎｋｏ Ｍ ｅｔ ａｌ．: 'Ｅｎｈａｎｃｅｍｅｎｔ ｂｙ ｏｔｈｅｒ ｃｏｍｐｏｕｎｄｓ ｏｆ ｔｈｅ ａｎｔｉ-ｃａｎｃｅｒ ａｃｔｉｖｉｔｙ ｏｆ ｖｉｔａｍｉｎ Ｄ（３） ａｎｄ ｉｔｓ ａｎａｌｏｇｓ．' Ｅｘｐ Ｃｅｌｌ Ｒｅｓ． ２９８（２）, 20040815, ３３９-５８
JPN7012004507; Ｓａｕｎｄｅｒｓ ＤＥ ｅｔ ａｌ．: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｒｅａｓｔ ａｎｄ ｏｖａｒｉａｎ ｃａｒｃｉｎｏｍａ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ １，２５-ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ Ｄ３ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｒｅｔ' Ａｎｔｉｃａｎｃｅｒ Ｄｒｕｇｓ． ６（４）, 199508, ５６２-９
JPN6012057652; Ｆｌａｉｇ ＴＷ: 'Ａ ｐｈａｓｅ ＩＩ ｔｒｉａｌ ｏｆ ｄｅｘａｍｅｔｈａｓｏｎｅ， ｖｉｔａｍｉｎ Ｄ， ａｎｄ ｃａｒｂｏｐｌａｔｉｎ ｉｎ ｐａｔｉｅｎｔｓ ｗｉｔｈ ｈｏｒｍｏｎｅ-ｒｅｆｒａｃｔｏｒｙ ｐｒ' Ｃａｎｃｅｒ １０７（２）, 20060715, ２６６-７４
JPN6012057656; Ｂｅｅｒ ＴＭ ｅｔ ａｌ．: 'Ｗｅｅｋｌｙ ｈｉｇｈ-ｄｏｓｅ ｃａｌｃｉｔｒｉｏｌ ａｎｄ ｄｏｃｅｔａｘｅｌ ｉｎ ｍｅｔａｓｔａｔｉｃ ａｎｄｒｏｇｅｎ-ｉｎｄｅｐｅｎｄｅｎｔ ｐｒｏｓｔａｔｅ ｃａｎｃｅｒ．' Ｊ Ｃｌｉｎ Ｏｎｃｏｌ ２１（１）, 200311, １２３-８
JPN6012057659; Ｔｒｕｍｐ ＤＬ ｅｔ ａｌ．: 'Ｐｈａｓｅ ＩＩ ｔｒｉａｌ ｏｆ ｈｉｇｈ-ｄｏｓｅ， ｉｎｔｅｒｍｉｔｔｅｎｔ ｃａｌｃｉｔｒｉｏｌ （１，２５ ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ Ｄ３） ａｎｄ ｄｅｘａｍｅｔｈａｓｏｎｅ ｉｎ' Ｃａｎｃｅｒ １０６（１０）, 20060515, ２１３６-４２
JPN7012004505; Ｐｅｅｈｌ ＤＭ: 'Ｐｒｅｃｌｉｎｉｃａｌ ａｃｔｉｖｉｔｙ ｏｆ ｋｅｔｏｃｏｎａｚｏｌｅ ｉｎ ｃｏｍｂｉｎａｔｉｏｎ ｗｉｔｈ ｃａｌｃｉｔｒｉｏｌ ｏｒ ｔｈｅ ｖｉｔａｍｉｎ Ｄ ａｎａｌｏｇｕｅ ＥＢ １０８' Ｊ Ｕｒｏｌ． １６８（４ Ｐｔ １）, 200210, １５８３-８
JPN5009015872; Ｋｏｓｈｉｚｕｋａ Ｋ: 'Ｃｏｍｂｉｎｅｄ ｅｆｆｅｃｔ ｏｆ ｖｉｔａｍｉｎ Ｄ３ ａｎａｌｏｇｓ ａｎｄ ｐａｃｌｉｔａｘｅｌ ｏｎ ｔｈｅ ｇｒｏｗｔｈ ｏｆ ＭＣＦ-７ ｂｒｅａｓｔ ｃａｎｃｅｒ ｃｅｌｌｓ ｉｎ ｖ' Ｂｒｅａｓｔ Ｃａｎｃｅｒ Ｒｅｓ Ｔｒｅａｔ． ５３（２）, 199901, １１３-１２０
JPN7012004506; Ｃｈｒｉｓｔｅｎｓｅｎ ＧＬ ｅｔ ａｌ．: 'Ｓｅｑｕｅｎｔｉａｌ ｖｅｒｓｕｓ ｃｏｍｂｉｎｅｄ ｔｒｅａｔｍｅｎｔ ｏｆ ｈｕｍａｎ ｂｒｅａｓｔ ｃａｎｃｅｒ ｃｅｌｌｓ ｗｉｔｈ ａｎｔｉｅｓｔｒｏｇｅｎｓ ａｎｄ ｔｈｅ ｖｉｔａｍｉｎ' Ｂｒｅａｓｔ Ｃａｎｃｅｒ Ｒｅｓ Ｔｒｅａｔ． ８５（１）, 200405, ５３-６３
JPN6012057667; Ｖｉｎｋ-ｖａｎ Ｗｉｊｎｇａａｒｄｅｎ Ｔ ｅｔ ａｌ．: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｒｅａｓｔ ｃａｎｃｅｒ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ ｃｏｍｂｉｎｅｄ ｔｒｅａｔｍｅｎｔ ｗｉｔｈ ｖｉｔａｍｉｎ Ｄ３ ａｎａｌｏｇｕｅｓ ａｎｄ ｔａｍｏｘｉｆｅ' Ｃａｎｃｅｒ Ｒｅｓ． ５４（２１）, 199411, ５７１１-７
JPN6012057670; Ｃｏｌｓｔｏｎ ＫＷ ｅｔ ａｌ．: 'Ｍｅｃｈａｎｉｓｍｓ ｉｍｐｌｉｃａｔｅｄ ｉｎ ｔｈｅ ｇｒｏｗｔｈ ｒｅｇｕｌａｔｏｒｙ ｅｆｆｅｃｔｓ ｏｆ ｖｉｔａｍｉｎ Ｄ ｉｎ ｂｒｅａｓｔ ｃａｎｃｅｒ．' Ｅｎｄｏｃｒ Ｒｅｌａｔ Ｃａｎｃｅｒ ９（１）, 200203, ４５-５９
JPN6012057673; Ｄａｎｉｌｅｎｋｏ Ｍ ｅｔ ａｌ．: 'Ｅｎｈａｎｃｅｍｅｎｔ ｂｙ ｏｔｈｅｒ ｃｏｍｐｏｕｎｄｓ ｏｆ ｔｈｅ ａｎｔｉ-ｃａｎｃｅｒ ａｃｔｉｖｉｔｙ ｏｆ ｖｉｔａｍｉｎ Ｄ（３） ａｎｄ ｉｔｓ ａｎａｌｏｇｓ．' Ｅｘｐ Ｃｅｌｌ Ｒｅｓ． ２９８（２）, 20040815, ３３９-５８
JPN7012004507; Ｓａｕｎｄｅｒｓ ＤＥ ｅｔ ａｌ．: 'Ｉｎｈｉｂｉｔｉｏｎ ｏｆ ｂｒｅａｓｔ ａｎｄ ｏｖａｒｉａｎ ｃａｒｃｉｎｏｍａ ｃｅｌｌ ｇｒｏｗｔｈ ｂｙ １，２５-ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ Ｄ３ ｃｏｍｂｉｎｅｄ ｗｉｔｈ ｒｅｔ' Ａｎｔｉｃａｎｃｅｒ Ｄｒｕｇｓ． ６（４）, 199508, ５６２-９
Attorney, Agent or Firm:
Toru Ishikawa