Title:
弱塩基性薬剤の固溶体を含む薬剤送達システム
Document Type and Number:
Japanese Patent JP2010502645
Kind Code:
A
Abstract:
The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 μg/mL at pH 6.8.
Inventors:
Venkatesh, Gopi
Boltri, Luigi
Colombo, Italo
Ray, Chin-One
Flavian, flabio
Mapelli, Luigi
Boltri, Luigi
Colombo, Italo
Ray, Chin-One
Flavian, flabio
Mapelli, Luigi
Application Number:
JP2009526896A
Publication Date:
January 28, 2010
Filing Date:
August 29, 2007
Export Citation:
Assignee:
Euland, Inc.
International Classes:
A61K47/32; A61K9/20; A61K9/50; A61K31/4422; A61K31/454; A61K31/455; A61K47/10; A61K47/12; A61K47/26; A61K47/34; A61K47/38; A61K47/40; A61P9/10; A61P9/12; A61P25/08; A61P25/18
Domestic Patent References:
| JP2003522141A | 2003-07-22 | |||
| JPH09104620A | 1997-04-22 | |||
| JPH0122245B2 | 1989-04-25 | |||
| JP2005508922A | 2005-04-07 | |||
| JP2002528485A | 2002-09-03 | |||
| JP2004339071A | 2004-12-02 | |||
| JP2000191519A | 2000-07-11 |
Foreign References:
| US20060057199A1 | 2006-03-16 | |||
| WO2005053689A2 | 2005-06-16 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Toshifumi Onuki