Title:
プロテアソームインヒビターと組み合わせてクラスIおよびクラスIIBヒストンデアセチラーゼに対する組み合わせ活性を持つヒストンデアセチラーゼインヒビター
Document Type and Number:
Japanese Patent JP2010503636
Kind Code:
A
Abstract:
The present invention is concerned with combinations of a proteasome inhibitor and a histone deacetylase inhibitor with combined activity on class-I and class-IIb histone deacetylases, for inhibiting the growth of tumor cells, useful in the treatment of cancer.
Inventors:
Alz, Janine
Heremance, Peter Willem Yang
Jean-Marie, Michel Marie Francois
Paige, Martin Jiyoung
Heremance, Peter Willem Yang
Jean-Marie, Michel Marie Francois
Paige, Martin Jiyoung
Application Number:
JP2009527807A
Publication Date:
February 04, 2010
Filing Date:
September 11, 2007
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/506; A61K31/69; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D403/14
Foreign References:
| WO2006010750A1 | 2006-02-02 |
Other References:
JPN6012043610; ＭＩＴＳＩＡＤＥＳ，Ｎ． ｅｔ ａｌ: Ｂｌｏｏｄ Ｖｏｌ．１０１， Ｎｏ．１０, 2003, ｐ．４０５５-４０６２
JPN6012043611; ＣＡＴＬＥＹ，Ｌ． ｅｔ ａｌ: Ｂｌｏｏｄ Ｖｏｌ．１０２， Ｎｏ．７, 2003, ｐ．２６１５-２６２２
JPN6012043612; ＰＥＩ，Ｘ． ｅｔ ａｌ: Ｂｌｏｏｄ Ｖｏｌ．１０２， Ｎｏ．１１, 2003, ｐ．６８５ａ
JPN6012043613; ＰＥＩ，Ｘ． ｅｔ ａｌ: Ｃｌｉｎｉｃａｌ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１０， Ｎｏ．１１, 2004, ｐ．３８３９-３８５２
JPN6012043614; ＡＤＪＥＩ，Ａ．Ａ．: Ｃｌｉｎｉｃａｌ Ｌｕｎｇ Ｃａｎｃｅｒ Ｖｏｌ．７， Ｓｕｐｐｌ． ２, 2005, ｐ．Ｓ５６-Ｓ５８
JPN6012043611; ＣＡＴＬＥＹ，Ｌ． ｅｔ ａｌ: Ｂｌｏｏｄ Ｖｏｌ．１０２， Ｎｏ．７, 2003, ｐ．２６１５-２６２２
JPN6012043612; ＰＥＩ，Ｘ． ｅｔ ａｌ: Ｂｌｏｏｄ Ｖｏｌ．１０２， Ｎｏ．１１, 2003, ｐ．６８５ａ
JPN6012043613; ＰＥＩ，Ｘ． ｅｔ ａｌ: Ｃｌｉｎｉｃａｌ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１０， Ｎｏ．１１, 2004, ｐ．３８３９-３８５２
JPN6012043614; ＡＤＪＥＩ，Ａ．Ａ．: Ｃｌｉｎｉｃａｌ Ｌｕｎｇ Ｃａｎｃｅｒ Ｖｏｌ．７， Ｓｕｐｐｌ． ２, 2005, ｐ．Ｓ５６-Ｓ５８
Attorney, Agent or Firm:
Patent business corporation Odashima patent office