Title:
フルオロメチル2,2,2-トリフロオロ-1-(トリフルオロメチル)エチルエーテルの製造方法
Document Type and Number:
Japanese Patent JP2010504917
Kind Code:
A
Abstract:
The present invention refers to a process for the preparation of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane) which includes a step that consists of reacting hexafluoroisopropanol with a formaldehyde equivalent selected among paraformaldehyde or 1,3,5-trioxane, a chlorinating agent selected from the group consisting of oxalyl chloride, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, sulfuryl chloride and thionyl chloride, and a strong acid selected from the group consisting of concentrated or fuming sulfuric acid resulting in the formation of the intermediate sevochlorane which is converted to sevoflurane in a second step which consists of reacting sevochlorane with an alkali metal fluoride, or a linear or branched chain tetra-alkyl quarternary ammonium fluoride in the presence of a sub-stoichiometric quantity of an alkali metal iodide, or a linear or branched alkyl chain tetra-alkyl quarternary ammonium iodide, preferably in a solvent.
Inventors:
Pacheco, Ogari
Teizeira, Antonio Carlos
Lima, Edson Ruiz
Bookelman, Maria Alice
Teizeira, Antonio Carlos
Lima, Edson Ruiz
Bookelman, Maria Alice
Application Number:
JP2009529473A
Publication Date:
February 18, 2010
Filing Date:
September 29, 2006
Export Citation:
Assignee:
Crystallia Produtos Kimikos Pharmachuticos Limiteda
International Classes:
C07C41/22; C07C41/01; C07C43/12
Domestic Patent References:
| JPS5665838A | 1981-06-03 | |||
| JP2002540179A | 2002-11-26 |
Foreign References:
| WO2006055748A2 | 2006-05-26 |
Attorney, Agent or Firm:
Hideo Takino
Sadao Matsumura
Fumio Takino
Sadao Matsumura
Fumio Takino