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Title:
ステアロイル-コエンザイムAデルタ-9デサチュラーゼの阻害剤としてのアザシクロアルカン誘導体
Document Type and Number:
Japanese Patent JP2010506859
Kind Code:
A
Abstract:
Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

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Inventors:
Obara, Renata, M
Dechenes, Dennis
Marc, Ganyon
Le blanc, eve
David Powell
Rmuthol, Eman, Kay
Application Number:
JP2009532660A
Publication Date:
March 04, 2010
Filing Date:
October 18, 2007
Export Citation:
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Assignee:
AXYS PHARMACEUTICALS, INC.
International Classes:
C07D401/14; A61K31/4545; A61K31/497; A61K31/501; A61K31/506; A61K31/53; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07D413/14; C07D417/14
Foreign References:
WO2006034315A22006-03-30
WO2006034440A22006-03-30
Attorney, Agent or Firm:
Kenji Ando
Yokoyama Isao



 
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