Title:
癌の治療に有用なポロ様キナーゼ阻害剤としてのプテリジン誘導体
Document Type and Number:
Japanese Patent JP2010507639
Kind Code:
A
Abstract:
Compound of formula (I) are inhibitors of Polo-like kinases (PLKs), and are useful in treatment of cell proliferative diseases: wherein R1 and R2 are hydrogen, or an optionally substituted (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl or (C3-C6)cycloalkyl group; R3 and R3′ are independently selected from hydrogen, —CN, hydroxyl, halogen, optionally substituted (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl or (C3-C6)cycloalkyl, —NR5R6 or C1-C4 alkoxy, wherein R5 and R6 are independently hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted mono- or bi-cyclic carbocyclic or heterocyclic ring or a ring system having up to 12 ring atoms; T is a radical of formula R-L1-Y1— wherein R is an alpha amino acid or alpha amino acid ester motif, linked to ring A by linker R-L1-Y1— as defined in the claims.
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Inventors:
Moffat, David, Festus, Charles
Patel, Sanjay, Lateral
Davis, Stephan, John
Baker, Kenneth, William, John
Philips, Oliver, James
Patel, Sanjay, Lateral
Davis, Stephan, John
Baker, Kenneth, William, John
Philips, Oliver, James
Application Number:
JP2009533934A
Publication Date:
March 11, 2010
Filing Date:
October 19, 2007
Export Citation:
Assignee:
CHROMA THERAPEUTICS LTD
International Classes:
C07D487/04; A61K31/519; A61P35/00; A61P35/02; A61P43/00
Attorney, Agent or Firm:
Shintaro Nogawa