アデノシン受容体へ作用する新規アミド

Japanese Patent JP2010509383

A

There are described Compounds of formula (I) in which R3 to R8 are independently selected from hydrogen, halogen, trihaloalkyl, alkyl having 1, 2, 3, 4 or 5 carbon atoms, electron donor groups selected from alkoxy having 1, 2, 3, 4 or 5 carbon atoms, trihaloalkoxy, hydroxy or amino, electron acceptor groups selected from cyano, sulphonic, nitro, or amide; R1 is an optionally substituted phenyl, benzyl or cyclohexyl group; R2 is selected from amino, substituted amino or guanidino groups, Z is a saturated or unsaturated C1-5 hydrocarbon chain, and salts thereof. A process for their preparation and compositions containing them are also described. The Compounds are either agonists or antagonists of a specific adenosine receptor or a number of adenosine receptors and have usefulness for the treatment of inflammation, arthritic conditions, rheumatoid arthritis, osteoarthritis, mental disorders, or for inducing central nerve regeneration.

Lundstedt, Torbjorn
Seifert, Elizabeth
Lek, p
Boman, Arne

JP2009536639A

March 25, 2010

November 09, 2007

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Accure Pharma AB

C07D209/14; A61K31/165; A61K31/4045; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P43/00

JP2004526722A	2004-09-02
JP2006516270A	2006-06-29

WO2006015357A2	2006-02-09
WO2006091936A2	2006-08-31

JPN6013009059; Ｔｅｔｒａｈｅｄｒｏｎ　Ｌｅｔｔｅｒｓ ４４, 2003, ６０３-６０５
JPN5009016393; Ｇ．ＢＥＲＧＮＥＳ: ＢＩＯＯＲＧＡＮＩＣ　ＡＮＤ　ＭＥＤＩＣＩＮＡＬ　ＣＨＥＭＩＳＴＲＹ　ＬＥＴＴＥＲＳ Ｖ９, 1999, Ｐ２８４９-２８５４
JPN5009016394; Ｆ．ＢＯＮＮＡＴＥＲＲＥ: ＯＲＧＡＮＩＣ　ＬＥＴＴＥＲＳ Ｖ８　Ｎ１９, 20060914, Ｐ４３５１-４３５４
JPN5009016395; Ｊ．ＺＨＡＮＧ: ＢＩＯＯＲＧＡＮＩＣ　ＡＮＤ　ＭＥＤＩＣＩＮＡＬ　ＣＨＥＭＩＳＴＲＹ Ｖ９, 2001, Ｐ８２５-８３６

Ikeuchi, Sato & Partners

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