Title:
インスリン様成長因子I受容体に対する抗体の阻害活性の評価方法
Document Type and Number:
Japanese Patent JP2010517024
Kind Code:
A
Abstract:
A method for the assessment of the inhibitory activity of an antibody for inhibiting the binding of IGF-1 and/or IGF-2 to IGF-1R in a lysed PBL sample of a mammal which has been treated with said antibody, characterized in that the IGF-1R protein level of said PBLs is measured as a measure for the inhibitory activity of said antibody.
More Like This:
Inventors:
Eiffel, Stephan
Hintz, Andreas
Kunkere, Claus-Peter
Hintz, Andreas
Kunkere, Claus-Peter
Application Number:
JP2009546703A
Publication Date:
May 20, 2010
Filing Date:
February 25, 2008
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K39/395; G01N33/53; A61P3/10
Domestic Patent References:
| JP2004531217A | 2004-10-14 |
Other References:
JPN5009020645; ＣＯＨＥＮ Ｂ Ｄ: ＣＬＩＮＩＣＡＬ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ Ｖ１１ Ｎ５, 20050301, Ｐ２０６３-２０７３, ＴＨＥ ＡＭＥＲＩＣＡＮ ＡＳＳＯＣＩＡＴＩＯＮ ＦＯＲ ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Tatsunori Ikeda
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Kazuhiro Nakamura
Tatsunori Ikeda