Title:
7-エチル-10-ヒドロキシカンプトテシンのマルチアームポリマー複合体を用いた抵抗性または難治性の癌の治療方法
Document Type and Number:
Japanese Patent JP2010518120
Kind Code:
A
Abstract:
A method of treating a resistant or refractory cancer in a mammal includes administering an effective amount of a compound of to the mammal. In preferred aspects, the cancer is resistant or refractory to CPT-11 or CPT therapy.
More Like This:
Inventors:
Zao, Hong
Supra, Puja
Supra, Puja
Application Number:
JP2009549259A
Publication Date:
May 27, 2010
Filing Date:
February 08, 2008
Export Citation:
Assignee:
ENZON PHARMACEUTICALS, INC.
International Classes:
A61K31/4375; A61K45/00; A61P1/04; A61P1/18; A61P11/00; A61P15/00; A61P15/14; A61P35/00; A61P35/02; A61P35/04; C08G65/333
Other References:
JPN6013001468; Ｚｈａｏ Ｈ ｅｔ ａｌ．: 'Ｎｏｖｅｌ ｐｒｏｄｒｕｇｓ ｏｆ ＳＮ３８ ｇｅｎｅｒａｔｅｄ ｂｙ ｍｕｌｔｉ-ａｒｍ ｐｏｌｙ（ｅｔｈｙｌｅｎｅ ｇｌｙｃｏｌ）' ＥＪＣ Ｓｕｐｐｌｅｍｅｎｔｓ Ｖｏｌ．４ Ｎｏ．１２, 200611, ｐ．５０
JPN6013001471; Ｓａｐｒａ Ｐ ｅｔ ａｌ．: 'Ｍａｒｋｅｄ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｉｃａｃｙ ｏｆ ａ ｎｏｖｅｌ ｐｏｌｙ（ｅｔｈｙｌｅｎｅ-ｇｌｙｃｏｌ） ｃｏｎｊｕｇａｔｅｄ ＳＮ３８ ｃｏｎｊｕｇａｔｅ ｉｎ ｘｅｎｏｇｒａｆｔ' ＥＪＣ Ｓｕｐｐｌｅｍｅｎｔｓ， Ｖｏｌ．４ Ｎｏ．１２, 200611, ｐ．４７
JPN6013001469; Ｓａｒｒｉｓ ＡＨ ｅｔ ａｌ．: 'Ｉｒｉｎｏｔｅｃａｎ ｉｎ ｒｅｌａｐｓｅｄ ｏｒ ｒｅｆｒａｃｔｏｒｙ ｎｏｎ-Ｈｏｄｇｋｉｎ'ｓ ｌｙｍｐｈｏｍａｓ． Ｉｎｄｉｃａｔｉｏｎｓ ｏｆ ａｃｔｉｖｉｔｙ ｉｎ ａ ｐｈａｓｅ ＩＩ' Ｏｎｃｏｌｏｇｙ Ｖｏｌ．１６ Ｎｏ．８ Ｓｕｐｐｌ． ７, 200208, ｐｐ．２７-３１
JPN6013001470; Ｇａｒｃｉａ-Ｇｉｒｏｎ Ｃ． ｅｔ ａｌ．: 'Ｐｈａｓｅ ＩＩ ｔｒｉａｌ ｏｆ ｆｏｒｔｎｉｇｈｔｌｙ ｉｒｉｎｏｔｅｃａｎ （ＣＰＴ-１１） ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｃｏｌｏｒｅｃｔａｌ ｃａｎｃｅｒ ｐａｔｉｅｎｔｓ ｒｅｓ' Ｃｌｉｎ Ｔｒａｎｓｌ Ｏｎｃｏｌ． Ｖｏｌ．７ Ｎｏ．６, 200507, ｐｐ．２４４-２４９
JPN6013001471; Ｓａｐｒａ Ｐ ｅｔ ａｌ．: 'Ｍａｒｋｅｄ ｔｈｅｒａｐｅｕｔｉｃ ｅｆｆｉｃａｃｙ ｏｆ ａ ｎｏｖｅｌ ｐｏｌｙ（ｅｔｈｙｌｅｎｅ-ｇｌｙｃｏｌ） ｃｏｎｊｕｇａｔｅｄ ＳＮ３８ ｃｏｎｊｕｇａｔｅ ｉｎ ｘｅｎｏｇｒａｆｔ' ＥＪＣ Ｓｕｐｐｌｅｍｅｎｔｓ， Ｖｏｌ．４ Ｎｏ．１２, 200611, ｐ．４７
JPN6013001469; Ｓａｒｒｉｓ ＡＨ ｅｔ ａｌ．: 'Ｉｒｉｎｏｔｅｃａｎ ｉｎ ｒｅｌａｐｓｅｄ ｏｒ ｒｅｆｒａｃｔｏｒｙ ｎｏｎ-Ｈｏｄｇｋｉｎ'ｓ ｌｙｍｐｈｏｍａｓ． Ｉｎｄｉｃａｔｉｏｎｓ ｏｆ ａｃｔｉｖｉｔｙ ｉｎ ａ ｐｈａｓｅ ＩＩ' Ｏｎｃｏｌｏｇｙ Ｖｏｌ．１６ Ｎｏ．８ Ｓｕｐｐｌ． ７, 200208, ｐｐ．２７-３１
JPN6013001470; Ｇａｒｃｉａ-Ｇｉｒｏｎ Ｃ． ｅｔ ａｌ．: 'Ｐｈａｓｅ ＩＩ ｔｒｉａｌ ｏｆ ｆｏｒｔｎｉｇｈｔｌｙ ｉｒｉｎｏｔｅｃａｎ （ＣＰＴ-１１） ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ｃｏｌｏｒｅｃｔａｌ ｃａｎｃｅｒ ｐａｔｉｅｎｔｓ ｒｅｓ' Ｃｌｉｎ Ｔｒａｎｓｌ Ｏｎｃｏｌ． Ｖｏｌ．７ Ｎｏ．６, 200507, ｐｐ．２４４-２４９
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma