Title:
組込み型光活性ペプチドおよびその使用
Document Type and Number:
Japanese Patent JP2010519338
Kind Code:
A
Abstract:
This invention is directed to the general method of transforming bioactive compounds of known structure and function into photoactive molecules such that the original biological activity is retained. The molecules resulting from the integration of two fundamental properties of photoactivity and biological function into a single molecular entity are hereinafter generally referred to as ‘integrated photoactive analogs’ or ‘integrated photoactive peptides or pseudopeptides.” The general method for the design of integrated photoactive analogs principally involves: (a) selecting a desired bioactive peptide or pseudopeptide; (b) identifying the region of the molecule that contains an aromatic or a heteroaromatic motif; and (c) either replacing said motif with a photoactive functional group of similar size, or modifying said motif to render it photoactive. Other aspects include photoactive analog compounds and photodiagnostic and phototherapeutic uses thereof.
Inventors:
Rajagopalan, Ragaban
Newman, William Elle.
Dorshaw, Richard Bee.
Newman, William Elle.
Dorshaw, Richard Bee.
Application Number:
JP2009551994A
Publication Date:
June 03, 2010
Filing Date:
February 26, 2008
Export Citation:
Assignee:
MALLINCKRODT INC.
International Classes:
A61K49/00; A61K41/00; A61K47/48; A61P15/00; A61P17/00; A61P35/00; A61P35/02; C07K7/08
Attorney, Agent or Firm:
Takeshi Oshio