クリックケミストリーを使用した炭酸脱水酵素-IXのための分子イメージングプローブの開発

Title:

クリックケミストリーを使用した炭酸脱水酵素-IXのための分子イメージングプローブの開発

Document Type and Number:

Japanese Patent JP2010523599

Kind Code:

A

Abstract:

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

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Inventors:

Corps, Hartmut See
Walsh, Joseph Sea
Oak, Dana Lakshmi
Mocarla, Vani
One, bottle
Ganga Harumato, Umesh Bee
Dacross, Brian A
Chen, Kai
Tsang, Way
Chain, gun
Paget, Henry Clifton
Karimi, Farhad
Scott, Peter JH
Gao, Ziyang
Rin, Kianwa
Kalia, Thomas Lee
Cao, Timin
Kusha, Chun Fan

Application Number:

JP2010502352A

Publication Date:

July 15, 2010

Filing Date:

April 07, 2008

Export Citation:

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Assignee:

Siemens Medical Solutions USA,Inc.

International Classes:

C07D249/04; A61K51/00; C07D249/06; C07D249/18; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D417/06; C07D417/12; C07D417/14

Domestic Patent References:

JP2006509844A

2006-03-23

Foreign References:

WO2006116736A2

2006-11-02

Other References:

JPN6012066388; Ｍｏｃｈａｒｌａ　ＶＰ　ｅｔ　ａｌ: Ａｎｇｅｗ　Ｃｈｅｍ　Ｉｎｔ　ＥｄＶｏｌ．４４, 2005, ｐ．１１６-１２０
JPN6012066389; Ｗｉｌｋｉｎｓｏｎ　ｅｔ　ａｌ: Ｊ　Ｍｅｄ　ＣｈｅｍＶｏｌ．４９, 2006, ｐ．６５３９-４８
JPN6012066391; Ｈｉｌｌｅｂｒｅｃｈｔ　Ａ　ｅｔ　ａｌ: ＣｈｅｍＭｅｄＣｈｅｍＶｏｌ．１, 2006, ｐ．８３９-５３
JPN6012066392; Ｓｉｎｇｈ　Ｓ　ｅｔ　ａｌ: ＡＲＫＩＶＯＣｘｖｉ, 2006, ｐ．１-１５
JPN6012066393; Ｓｃｏｚｚａｆａｖａ　Ａ　ｅｔ　ａｌ: Ｊ　Ｍｅｄ　ＣｈｅｍＶｏｌ．４３, 2000, ｐ．４５４２-５１

Attorney, Agent or Firm:

Iwao Yamaguchi

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