Title:
ベンゾオキサゾールアリールアミドから誘導されたCETP阻害剤
Document Type and Number:
Japanese Patent JP2010530416
Kind Code:
A
Abstract:
Compounds having the structure of Formula I1 including pharmaceutically acceptable salts of the compounds, are potent CETP (cholesterol ester transfer protein) inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis Atherosclerosis and its clinical consequences, coronary heart disease (CHD), stroke and penpheral vascular disease, represent a truly enormous burden to the health care systems of the industrialized world In formula I, A-B is an arylamide moiety.
Inventors:
Hunt, The Julianne A
Swiss, Ramsey Eff
Kim, Doosop
Mustard, florida
Sinclair, Peter Theei
Swiss, Ramsey Eff
Kim, Doosop
Mustard, florida
Sinclair, Peter Theei
Application Number:
JP2010513202A
Publication Date:
September 09, 2010
Filing Date:
June 16, 2008
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D413/10; A61K31/454; A61K31/4545; A61K31/506; A61K31/5377; A61K31/553; A61K45/00; A61P3/04; A61P3/06; A61P9/10; A61P9/12; A61P43/00; C07D413/12; C07D413/14; C07D471/10
Domestic Patent References:
| JP2001512416A | 2001-08-21 | |||
| JPH09501944A | 1997-02-25 | |||
| JPH04327586A | 1992-11-17 | |||
| JP2001526283A | 2001-12-18 | |||
| JP2003503390A | 2003-01-28 |
Foreign References:
| WO1995030659A1 | 1995-11-16 | |||
| US4714762A | 1987-12-22 | |||
| WO1997043255A1 | 1997-11-20 | |||
| US20030148387A1 | 2003-08-07 | |||
| WO2006014413A1 | 2006-02-09 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Chihiro Watanabe
Katsuma Osaki
Mitsuaki Tsubokura
Chihiro Watanabe
Katsuma Osaki
Mitsuaki Tsubokura