神経変性疾患におけるCD44スプライスバリアント

Japanese Patent JP2010532989

A

There is provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression of ribonucleic acid (RNA) encoded by a nucleic acid, wherein the nucleic acid is selected from a group that includes a contiguous nucleotide sequence being at least 90% homologous to at least 20 nucleotides of: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, or any combination thereof. There is further provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression and/or activity of a polypeptide, wherein the sequence of the polypeptide is selected from a group that includes a contiguous amino acid sequence being at least 90% homologous to at least 10 amino acid of: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or any combination thereof.

JPH06189766	DNA SEQUENCE CODING ZONA PELLUCIDA CZP2 OF CANINE OVUM
JP2004535183	Genes and their use
WO/2001/077676	T2R TASTE RECEPTORS AND GENES ENCODING SAME

Pinner Elhanan
Rhodon moche
Jisaper Nava

JP2010515648A

October 21, 2010

July 10, 2008

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New Rim Pharmaceuticals (1991) Limited

C12N15/09; A61K31/7088; A61K31/7105; A61K31/711; A61K39/395; A61K45/00; A61K48/00; A61P21/00; A61P25/00; A61P25/16; A61P25/28; C07K14/725; C12Q1/68; G01N33/53

JPN6013012230; Ｉｍｍｕｎｏｌ．　Ｔｏｄａｙ，　１９９３，　１４（８），　ｐｐ．３９５-３９９
JPN6013012235; Ｉｎｆｅｃｔ．　Ｉｍｍｕｎ．，　２００５，　７３（１），　ｐｐ．５０-６１
JPN6013012238; Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ．，　２００６，　２８１（４５），　ｐｐ．３４３８１-３４３９３
JPN6013012227; Ｊ．　Ｎｅｕｒｏｃｙｔｏｌ．，　１９９２，　２１（５），　ｐｐ．３６３-３７３
JPN6013012242; Ｂｒａｉｎ　Ｒｅｓ．，　１９９３，　６３２（１-２），　ｐｐ．２４９-２５９
JPN6013012230; Ｉｍｍｕｎｏｌ．　Ｔｏｄａｙ，　１９９３，　１４（８），　ｐｐ．３９５-３９９

Masayuki Masabayashi
Hayashi Ichiyoshi

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