Title:
β1-アドレナリン作動性レセプター抗体を阻害する変異体二重環化レセプターペプチド
Document Type and Number:
Japanese Patent JP2010536356
Kind Code:
A
Abstract:
The present invention relates to novel ²-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopeptide-mutants and linear peptides. Moreover, vectors and recombinant host cells comprising said nucleic acid molecule and a method for producing the disclosed cyclopeptide-mutants are provided. Further provided is a composition comprising the peptides, nucleic acid molecules, vectors or host cells of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptides of the invention and to means, methods and uses for detecting anti-²-adrenergic receptor antibodies like anti-² 1 -adrenergic receptor antibodies.
Inventors:
Jaens, Roland
Jaens, valerie
Rose, martin
Nikolaev, Viacheslav
Jaens, valerie
Rose, martin
Nikolaev, Viacheslav
Application Number:
JP2010521365A
Publication Date:
December 02, 2010
Filing Date:
August 22, 2008
Export Citation:
Assignee:
Julius-Maximilians-Universitate Wurzburg
International Classes:
C12N15/09; A61K35/76; A61K38/00; A61K48/00; A61P9/00; A61P9/04; A61P9/06; A61P9/10; C07K14/72; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; G01N33/53
Domestic Patent References:
| JP2003514772A | 2003-04-22 | |||
| JP2003514772A | 2003-04-22 |
Foreign References:
| WO2006103101A2 | 2006-10-05 | |||
| WO2006103101A2 | 2006-10-05 |
Attorney, Agent or Firm:
Yoshinori Hosoda