Title:
FXRアゴニストとして使用されるベンゾイミダゾール誘導体
Document Type and Number:
Japanese Patent JP2010536915
Kind Code:
A
Abstract:
The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
Inventors:
Benson, Gregory Martin
Breicher, Konrad
Greetter, uwe
Martin, Rainer A
Plancher, Jean-Marc
Richter, Hans
Taylor, Sven
Yang, Min Min
Breicher, Konrad
Greetter, uwe
Martin, Rainer A
Plancher, Jean-Marc
Richter, Hans
Taylor, Sven
Yang, Min Min
Application Number:
JP2010522312A
Publication Date:
December 02, 2010
Filing Date:
August 19, 2008
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D235/06; A61K31/4184; A61P1/16; A61P3/06; A61P3/10; A61P9/10; A61P19/10; A61P25/16; A61P25/28; A61P35/00; A61P43/00; C07D235/12; C07D405/06; C07D405/12
Domestic Patent References:
| JP2009541413A | 2009-11-26 | |||
| JP2005526028A | 2005-09-02 | |||
| JP2007521296A | 2007-08-02 | |||
| JP2009541413A | 2009-11-26 | |||
| JP2005526028A | 2005-09-02 | |||
| JP2007521296A | 2007-08-02 |
Foreign References:
| WO2003024937A1 | 2003-03-27 | |||
| WO2003024937A1 | 2003-03-27 |
Other References:
JPN5010011293; ＴＥＭＰＥＳＴ Ｐ: ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４２ Ｎ３０, 20010723, Ｐ４９５９-４９６２, ＥＬＳＥＶＩＥＲ
JPN7012004230; 薬学雑誌 １２８（３）, 2008, ３４３-３５５
JPN5010011293; ＴＥＭＰＥＳＴ Ｐ: ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４２ Ｎ３０, 20010723, Ｐ４９５９-４９６２, ＥＬＳＥＶＩＥＲ
JPN7012004230; 薬学雑誌 １２８（３）, 2008, ３４３-３５５
JPN7012004230; 薬学雑誌 １２８（３）, 2008, ３４３-３５５
JPN5010011293; ＴＥＭＰＥＳＴ Ｐ: ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４２ Ｎ３０, 20010723, Ｐ４９５９-４９６２, ＥＬＳＥＶＩＥＲ
JPN7012004230; 薬学雑誌 １２８（３）, 2008, ３４３-３５５
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito