Title:
癌の治療における葉酸代謝拮抗剤の併用
Document Type and Number:
Japanese Patent JP2010538967
Kind Code:
A
Abstract:
Compositions and methods useful in the treatment of certain cancers. The methods include administering, to a patient receiving an antifolate anticancer agent, methoxyamine administered in an amount sufficient to enhance or increase the effect of the antifolate anticancer agent. In part, this application is based on the recognition that certain molecules that target abasic lesions or AP sites in DNA improve, augment, or potentiate the chemotherapeutic efficacy of certain anticancer agents.
Inventors:
Sawell, Charles, Pee.
Adams, Bourne, Jane
Adams, Bourne, Jane
Application Number:
JP2009544233A
Publication Date:
December 16, 2010
Filing Date:
December 21, 2007
Export Citation:
Assignee:
Tracon Pharmaceuticals, Inc.
International Classes:
A61K31/131; A61K31/519; A61P35/00; A61P43/00
Domestic Patent References:
| JP2002539126A | 2002-11-19 | |||
| JP2005517007A | 2005-06-09 | |||
| JP2006508117A | 2006-03-09 |
Foreign References:
| CN1846679A | 2006-10-18 | |||
| WO2003070234A1 | 2003-08-28 | |||
| CN1846679A | 2006-10-18 | |||
| WO2003070234A1 | 2003-08-28 |
Other References:
JPN6012027249; Ｒｉｃｈａｒｄｓ Ｒ．Ｇ． ｅｔ．ａｌ．: ＢＡＳＩＣ ＬＩＦＥ ＳＣＩＥＮＣＥＳ Ｖｏｌ．３１, 1985, ｐ．１４９-１６２
JPN6012027245; Ｇｅｒｓｏｎ Ｓ．Ｌ． ｅｔ．ａｌ．: '"４５８ ＩＮＶＩＴＥＤ Ｂａｓｅ ｅｘｃｉｓｉｏｎ ｒｅｐａｉｒ ｉｎｈｉｂｉｔｉｏｎ： ａ ｎｅｗ ｔａｒｇｅｔ ｆｏｒ ｃａｎｃｅｒ ｔｈｅｒａｐｙ"' ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ ＳＵＰＰＬＥＭＥＮＴ Ｖｏｌ．４， Ｎｏ．１２, 20061101, ｐ．１４０-１４１
JPN6012027249; Ｒｉｃｈａｒｄｓ Ｒ．Ｇ． ｅｔ．ａｌ．: ＢＡＳＩＣ ＬＩＦＥ ＳＣＩＥＮＣＥＳ Ｖｏｌ．３１, 1985, ｐ．１４９-１６２
JPN6012027245; Ｇｅｒｓｏｎ Ｓ．Ｌ． ｅｔ．ａｌ．: '"４５８ ＩＮＶＩＴＥＤ Ｂａｓｅ ｅｘｃｉｓｉｏｎ ｒｅｐａｉｒ ｉｎｈｉｂｉｔｉｏｎ： ａ ｎｅｗ ｔａｒｇｅｔ ｆｏｒ ｃａｎｃｅｒ ｔｈｅｒａｐｙ"' ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ ＳＵＰＰＬＥＭＥＮＴ Ｖｏｌ．４， Ｎｏ．１２, 20061101, ｐ．１４０-１４１
JPN6012027249; Ｒｉｃｈａｒｄｓ Ｒ．Ｇ． ｅｔ．ａｌ．: ＢＡＳＩＣ ＬＩＦＥ ＳＣＩＥＮＣＥＳ Ｖｏｌ．３１, 1985, ｐ．１４９-１６２
Attorney, Agent or Firm:
Hiroe Associates Patent Office