Title:
ベンジル・シクロアルキル・スフィンゴシン1‐リン酸受容体修飾薬
Document Type and Number:
Japanese Patent JP2010540561
Kind Code:
A
Abstract:
Sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type are provided. The disclosed compounds include an optional phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.
Inventors:
Lynch, Kevin Earl.
McDonald's, Timothy El.
McDonald's, Timothy El.
Application Number:
JP2010527241A
Publication Date:
December 24, 2010
Filing Date:
September 29, 2008
Export Citation:
Assignee:
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
International Classes:
C07C215/42; A61K31/136; A61K31/661; A61K31/662; A61P1/04; A61P3/10; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P37/06; A61P43/00; C07D207/22; C07F9/09
Attorney, Agent or Firm:
Yoshiyuki Osuga