Title:
その使用としてのGDF8に対する抗体
Document Type and Number:
Japanese Patent JP2011504096
Kind Code:
A
Abstract:
The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti-GDF8 antibodies or antigen binding protein or fragment thereof that may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8-associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
Inventors:
Edward roland lavalier
Lisa Ann Collins-Lacy
Christopher John Corcoran
Rio Udomira Genaday Evena Cistia Kouva
John Adam No Work
Liez Karim
Shiyan-Yang Tan
Kimberley Ann Market
The Art Ruida Matchteld Verdmann
Lisa Ann Collins-Lacy
Christopher John Corcoran
Rio Udomira Genaday Evena Cistia Kouva
John Adam No Work
Liez Karim
Shiyan-Yang Tan
Kimberley Ann Market
The Art Ruida Matchteld Verdmann
Application Number:
JP2010532058A
Publication Date:
February 03, 2011
Filing Date:
October 31, 2008
Export Citation:
Assignee:
Weiss LRC
International Classes:
C12N15/09; A61K38/00; A61K39/395; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P5/18; A61P11/00; A61P15/00; A61P19/00; A61P19/10; A61P21/00; A61P21/02; C07K16/22; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; G01N33/53; G01N33/543; G01N33/577
Domestic Patent References:
| JP2005510212A | 2005-04-21 |
Foreign References:
| WO2006116269A2 | 2006-11-02 | |||
| WO2007047112A2 | 2007-04-26 | |||
| WO2005094446A2 | 2005-10-13 | |||
| WO2007044411A2 | 2007-04-19 | |||
| WO2006107611A2 | 2006-10-12 | |||
| WO2006102574A2 | 2006-09-28 |
Attorney, Agent or Firm:
Yoshinobu Murofushi
High Hoji Koji
Junko Miyazawa
Noh four
High Hoji Koji
Junko Miyazawa
Noh four