Title:
C型ナトリウム利尿ペプチドの変異体
Document Type and Number:
Japanese Patent JP2011504506
Kind Code:
A
Abstract:
The present invention provides variants of C-type natriuretic peptide (CNP) comprising one or more deletions; additions of and/or substitutions with natural amino acids, unnatural amino acids and/or peptidomimetics (including peptide bond isosteres); amino acid extensions; and/or other chemical moieties such as, e.g., poly(ethylene glycol) and hydrophobic acids. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders such as, e.g., skeletal dysplasias and achondroplasia, and vascular smooth muscle disorders such as, e.g., restenosis and arteriosclerosis.
Inventors:
Went, Dan Jay.
Blue Yanagi -Share bar Mika
Bell sean
Way, don
Kakis, Emil Dee.
Breathus, Joshua Earl.
Blue Yanagi -Share bar Mika
Bell sean
Way, don
Kakis, Emil Dee.
Breathus, Joshua Earl.
Application Number:
JP2010535081A
Publication Date:
February 10, 2011
Filing Date:
November 21, 2008
Export Citation:
Assignee:
Biomarine Pharmaceutical Incorporated
International Classes:
C07K14/00; A61K38/00; A61P7/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P19/00; C07K7/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita