Title:
寄生虫疾患を治療するためのシステインプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2011504883
Kind Code:
A
Abstract:
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the treatment and/or prevention of these parasitic diseases including; toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, schistosomiasis, amebiasis, giardiasis, clonorchiasis, opisthorchiasis, paragonimiasis, fasciolopsiasis, lymphatic filariasis, onchocerciasis, dracunculiasis, ascariasis, trichuriasis, stronglyoidiasis, trichostrongyliasis, trichomoniasis or cestodiasis.
Inventors:
Isabel, Elise
Melon, christophe
Beaulieu, Kristian
Melon, christophe
Beaulieu, Kristian
Application Number:
JP2010535184A
Publication Date:
February 17, 2011
Filing Date:
November 26, 2008
Export Citation:
Assignee:
AXYS PHARMACEUTICALS, INC.
International Classes:
C07C255/44; A61K31/277; A61K31/40; A61K31/4245; A61K31/4406; A61K31/4425; A61K31/495; A61K31/5375; A61K45/00; A61P33/00; A61P33/02; A61P33/04; A61P33/06; A61P33/10; A61P33/12; A61P43/00; C07C255/46; C07C255/60; C07C311/37; C07C317/32; C07C317/50; C07C321/24; C07D207/335; C07D213/57; C07D213/89; C07D271/06; C07D295/12; C07D295/16
Domestic Patent References:
| JP2005526753A | 2005-09-08 | |||
| JPH054958A | 1993-01-14 |
Foreign References:
| WO2007012180A1 | 2007-02-01 |
Other References:
LEGER, SERGE 他: "Primary amides as selective inhibitors of cathepsin K", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 17(15), JPN6013042337, 2007, pages 4328 - 4332, ISSN: 0002764758
Attorney, Agent or Firm:
Kawaguchi International Patent Office