グルココルチコイド受容体アゴニストとしてのC-21チオエーテル

Title:

グルココルチコイド受容体アゴニストとしてのC-21チオエーテル

Document Type and Number:

Japanese Patent JP2011507879

Kind Code:

A

Abstract:

The present invention provides compounds of Formula (VII) and 11-keto analogs thereof, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, and isomers of said compounds and said 11-keto analogs, having the general structure formula (VII): wherein L, R1, R2, R3, R4, and R5 are selected independently of each other and as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions. The novel compounds of the present invention possess useful pharmacological activity while having unexpectedly low systemic activity. Thus, the compounds of the invention represent a safer alternative to those known glucocorticoids which have poor side-effect profiles.

More Like This:

WO/2017/148977	PRODRUGS OF THE SELECTIVE PROGESTERONE RECEPTOR MODULATOR (SPRM) (11.BETA.,17.BETA.)-17-HYDROXY-11-[4-(METHYLSULPHONYL)PHENYL]-17-(PENTAFLUOROETH YL)ESTRA-4,9-DIEN-3-ONE
JP3549125	Corticoid 17,21-dicarboxylic acid ester and corticosteroid 17-carboxylic acid ester 21-carbonate ester, their manufacturing methods and pharmaceuticals containing these compounds
JP3759639	22-THIAVITAMIN D3 DERIVATIVE

Inventors:

Antes, John Sea.
McCormick, Kevin Dee.
Hey, John A.
Aslanian, Robert G.
Biju, Praccat Le Jay.
Berlin, Michael Wye.
Solomon, Daniel M.

Application Number:

JP2010539763A

Publication Date:

March 10, 2011

Filing Date:

December 18, 2008

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Schering Corporation

International Classes:

C07J31/00; A61K31/573; A61K31/58; A61K45/00; A61P1/04; A61P11/00; A61P11/02; A61P11/04; A61P11/06; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07J43/00; C07J71/00

Domestic Patent References:

JP2008546694A	2008-12-25
JPS5030863A	1975-03-27
JPH11501676A	1999-02-09
JPS6289694A	1987-04-24
JP2011507878A	2011-03-10

Foreign References:

US5420120A

1995-05-30

Other References:

JPN6013038029; Ｃｈｅｍｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ３７（７）, 1989, １７９５-１８０１
JPN6013038031; Ｃｈｅｍｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ３７（１２）, 1989, ３２８６-３２９３
JPN6013038017; Ｂｉｏｃｈｅｍｉｓｔｒｙ１８（２２）, 1979, ４９１５-４９２２
JPN6013038019; Ｓｔｅｒｏｉｄｓ１８（４）, 1971, ４２１-４３２
JPN6013038022; Ｂｉｏｃｈｅｍｉｃａｌ　Ｐｈａｒｍａｃｏｌｏｇｙ１２, 1963, １０８１-１０９０
JPN6013038024; Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ２６, 1961, ５０５２-５０５４
JPN6013038026; Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ１２（５）, 1969, ８１０-８１８

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

Previous Patent: JP2011507878

Next Patent: 慢性リンパ性白血病の処置のためのニロチニブとナイトロジェンマスター�...