代謝異常の治療のための化合物

Japanese Patent JP2011509942

A

Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. The agent is a compound of Formula (I): wherein m is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R1 is hydrogen or alkyl having from 1 to 3 carbon atoms; and R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula I by a ring carbon; Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula (I).

Shama Sharini
Bon Beauster Raid W.

JP2010542415A

March 31, 2011

January 13, 2009

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Welstat Therapeutics Corporation

C07C69/773; A61K31/235; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P9/10; A61P9/12; A61P13/12; A61P15/00; A61P17/02; A61P25/02; A61P27/12

JPS6284054A	1987-04-17
JP2006507303A	2006-03-02

US20020161050A1	2002-10-31
US3772389A	1973-11-13

JPN6013045044; Ｓｙｎｌｅｔｔ （７）, 1990, ４２１-４２３
JPN6013045043; Ｉｎｄｉａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｈｅｍｉｓｔｒｙ，　Ｓｅｃｔｉｏｎ　Ｂ ４６Ｂ（９）, 2007, １５５４-１５５７
JPN6013045045; Ｊｏｕｒｎａｌ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ，　Ｃｈｅｍｉｃａｌ　Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ （１５）, 1981, ７４５

Masaki Hirota

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