Title:
核酸送達複合体の溶出のための装置及び方法
Document Type and Number:
Japanese Patent JP2011509944
Kind Code:
A
Abstract:
Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a method of making a medical device. The method can include complexing nucleic acids with a carrier agent to form a delivery complex solution, applying the delivery complex solution to a substrate, and applying a polymeric solution to the substrate. In another embodiment, the invention includes a method of making a medical device including complexing nucleic acids with a carrier agent to form nucleic acid delivery complexes, combining the nucleic acid delivery complexes with a polymer solution and a cross-linking agent, wherein the cross-linking agent is positively charged or charge neutral. In an embodiment, the invention includes an implantable medical device including a substrate and a coating disposed on a surface of the substrate, the coating comprising a polymeric matrix and a plurality of disperse nucleic acid delivery complexes disposed within the polymeric matrix. Other embodiments are included herein.
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Inventors:
Johnson, Elizabeth E.
Anderson, Aron Brent
McGonigle, Joseph Schmidt
Anderson, Aron Brent
McGonigle, Joseph Schmidt
Application Number:
JP2010542430A
Publication Date:
March 31, 2011
Filing Date:
January 14, 2009
Export Citation:
Assignee:
Thermodix, Incorporated
International Classes:
A61K31/7088; A61K9/00; A61K31/711; A61K47/18; A61K47/32; A61K47/36; A61K47/48; A61K48/00; A61P27/02; C12N15/09
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Nagasaka Tomoyasu
Yoshihiro Kobayashi
Satoshi Deno
Takashi Ishida
Tetsuji Koga
Nagasaka Tomoyasu
Yoshihiro Kobayashi
Satoshi Deno