Title:
B型肝炎ウイルス(HBV)の疎水性修飾されたpreS由来ペプチド及び肝臓に化合物を特異的に送達するためのビヒクルとしてのそれらの使用
Document Type and Number:
Japanese Patent JP2011512123
Kind Code:
A
Abstract:
The present invention relates to hydrophobic modified preS-derived peptides of hepatitis B virus (HBV) which are versatile vehicles for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. Any kind of compound, but in particular drugs, such as interferons, viral reverse transcriptase inhibitors or core assembly inhibitors, and/or labels can be specifically targeted to the liver and so be enriched in the liver. This liver targeting can further be used for the targeted diagnosis, prevention and/or treatment of liver diseases or disorders, such as hepatitis, malaria, hepatocellular carcinoma (HCC), as well as for the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified preS-derived peptide(s) and the compound(s) to be specifically delivered to the liver. The present invention furthermore relates to a method for the combined treatment of a liver disease and the prevention of HAV, HBV, HCV and/or HDV infection. The present invention relates also to the use of the preS-derived peptides in gene therapy and the delivery of immunogenic epitopes for hepatocyte-mediated antigen presentation to activate liver-directed immunological responses.
Inventors:
Miel, walter
Huberkorn, Uwe
Urban, Stephan
Huberkorn, Uwe
Urban, Stephan
Application Number:
JP2010543441A
Publication Date:
April 21, 2011
Filing Date:
January 26, 2009
Export Citation:
Assignee:
Ruprecht-Karls-Universitaet Heidelberg
International Classes:
C12N15/09; A61K38/16; A61K39/29; A61P1/16; A61P31/20; C07K14/02; G01N33/576; A61K39/00; C07K14/52
Domestic Patent References:
| JP2004536886A | 2004-12-09 |
Other References:
JPN6013055458; Ｊ． Ｖｉｒｏｌ．， ２００５， Ｖｏｌ．７９， Ｎｏ．３， ｐ．１６１３-１６２２
JPN6013055459; Ｊ． Ｈｅｐａｔｏｌｏｇｙ， Ｖｏｌ．４４， ｐ．Ｓ１６，
JPN6013055460; Ｍｏｌｅｃｕｌａｒ Ｉｍｍｕｎｏｌｏｇｙ， １９８９， Ｖｏｌ．２６， Ｎｏ．１， ｐ．５３-６２
JPN6013055461; Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ， ２００５， Ｖｏｌ．１２９， ｐ．２３４-２４５
JPN6013055459; Ｊ． Ｈｅｐａｔｏｌｏｇｙ， Ｖｏｌ．４４， ｐ．Ｓ１６，
JPN6013055460; Ｍｏｌｅｃｕｌａｒ Ｉｍｍｕｎｏｌｏｇｙ， １９８９， Ｖｏｌ．２６， Ｎｏ．１， ｐ．５３-６２
JPN6013055461; Ｇａｓｔｒｏｅｎｔｅｒｏｌｏｇｙ， ２００５， Ｖｏｌ．１２９， ｐ．２３４-２４５
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Hirata Midori
Yuriko Shinobu
Takuya Osugi
Aki Soga
Hirata Midori