Title:
C型肝炎ウイルス阻害剤としてのフッ素化大環状化合物
Document Type and Number:
Japanese Patent JP2011515413
Kind Code:
A
Abstract:
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Inventors:
Guy, Yonghua
Oa, Yatto Seung
One, Jia
Oa, Yatto Seung
One, Jia
Application Number:
JP2011500960A
Publication Date:
May 19, 2011
Filing Date:
March 19, 2009
Export Citation:
Assignee:
Enanta Pharmaceuticals, Inc.
International Classes:
C07D498/08; A61K31/5395; A61K38/21; A61P31/12; A61P31/14; C07D498/18
Foreign References:
| WO2007148135A1 | 2007-12-27 | |||
| WO2007131966A1 | 2007-11-22 | |||
| WO2007015855A1 | 2007-02-08 | |||
| WO2008021733A2 | 2008-02-21 | |||
| WO2008021871A2 | 2008-02-21 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office