Title:
改善された薬物速度論的および薬力学的特性を有するエトミデート類似体
Document Type and Number:
Japanese Patent JP2011516487
Kind Code:
A
Abstract:
The invention is directed to compounds according to formula (I):
where R 1 is L 1 C(O)OT or L 1 C(O)OL 2 C(O)OT; R 2 is a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, or R 1 ; n is an integer from 0 to 5; each R 3 is independently halogen or R 2 ; L 1 and L 2 are each independently a bond, a substituted or unsubstituted C 1 -C 10 alkylene, C 2 -C 10 alkenylene, or C 2 -C 10 alkynylene; and T is H, a substituted or unsubstituted C 1 -C 10 alkyl, C 2 -C 10 alkenyl, or C 2 -C 10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.
Inventors:
Raynes Douglas E.
Forman Stuart A.
Mirror Keith W.
Hussein Sid show cut
Kotten Joseph F.
Forman Stuart A.
Mirror Keith W.
Hussein Sid show cut
Kotten Joseph F.
Application Number:
JP2011503087A
Publication Date:
May 26, 2011
Filing Date:
March 31, 2009
Export Citation:
Assignee:
The General Hospital Corporation
International Classes:
C07D233/90; A61K31/4174; A61P23/00
Domestic Patent References:
| JPS6419070A | 1989-01-23 | |||
| JPS51115473A | 1976-10-12 | |||
| JPS6419070A | 1989-01-23 |
Foreign References:
| WO1996039137A1 | 1996-12-12 | |||
| US3354173A | 1967-11-21 | |||
| WO1996039137A1 | 1996-12-12 |
Other References:
JPN7013003448; Ｉｎｓｅｃｔ Ｂｉｏｃｈｅｍ． Ｍｏｌｅｃ．Ｂｉｏｌ． ２７（２）, 1997, １０１-１０８
JPN7013003449; ＰＲＯＴＥＩＮＳ：Ｓｔｒｕｃｔｕｒｅ，Ｆｕｎｃｔｉｏｎ，ａｎｄ Ｂｉｏｉｎｆｏｒｍａｔｉｃｓ ５９, 2005, ６４-７１
JPN7013003443; Ｊ．Ｍｅｄ．Ｃｈｅｍ． ４６（７）, 2003, １２５７-１２６５
JPN7013003444; Ｊ．Ｏｒｇ．Ｃｈｅｍ． ５２（１６）, 1987, ３５９１-３５９４
JPN7013003445; Ｃｈｅｍ．Ｒｅｓ．Ｔｏｘｉｃｏｌ． ２０（１０）, 2007, １４４２-１４５２
JPN7013003446; Ｄａｔａｂａｓｅ Ｒｅｇｉｓｔｒｙ ｏｎ ＳＴＮ，ＲＮ ２０５８２９-２５-０，Ｅｎｔｅｒｅｄ ＳＴ
JPN7013003448; Ｉｎｓｅｃｔ Ｂｉｏｃｈｅｍ． Ｍｏｌｅｃ．Ｂｉｏｌ． ２７（２）, 1997, １０１-１０８
JPN7013003449; ＰＲＯＴＥＩＮＳ：Ｓｔｒｕｃｔｕｒｅ，Ｆｕｎｃｔｉｏｎ，ａｎｄ Ｂｉｏｉｎｆｏｒｍａｔｉｃｓ ５９, 2005, ６４-７１
JPN7013003449; ＰＲＯＴＥＩＮＳ：Ｓｔｒｕｃｔｕｒｅ，Ｆｕｎｃｔｉｏｎ，ａｎｄ Ｂｉｏｉｎｆｏｒｍａｔｉｃｓ ５９, 2005, ６４-７１
JPN7013003443; Ｊ．Ｍｅｄ．Ｃｈｅｍ． ４６（７）, 2003, １２５７-１２６５
JPN7013003444; Ｊ．Ｏｒｇ．Ｃｈｅｍ． ５２（１６）, 1987, ３５９１-３５９４
JPN7013003445; Ｃｈｅｍ．Ｒｅｓ．Ｔｏｘｉｃｏｌ． ２０（１０）, 2007, １４４２-１４５２
JPN7013003446; Ｄａｔａｂａｓｅ Ｒｅｇｉｓｔｒｙ ｏｎ ＳＴＮ，ＲＮ ２０５８２９-２５-０，Ｅｎｔｅｒｅｄ ＳＴ
JPN7013003448; Ｉｎｓｅｃｔ Ｂｉｏｃｈｅｍ． Ｍｏｌｅｃ．Ｂｉｏｌ． ２７（２）, 1997, １０１-１０８
JPN7013003449; ＰＲＯＴＥＩＮＳ：Ｓｔｒｕｃｔｕｒｅ，Ｆｕｎｃｔｉｏｎ，ａｎｄ Ｂｉｏｉｎｆｏｒｍａｔｉｃｓ ５９, 2005, ６４-７１
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto