Title:
Sykチロシンキナーゼタンパク質が関与している代謝経路を阻害する分子および前記分子を同定するための方法
Document Type and Number:
Japanese Patent JP2011518133
Kind Code:
A
Abstract:
The present invention relates to the C-13 molecule (methyl 2-{5-[(3-benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}-benzoate) and to organic molecules functionally equivalent to the C-13 molecule, capable of inhibiting the binding of an antibody or antibody fragment with the human Syk protein tyrosine kinase, to the use of these molecules for the production of medicaments for the prevention or treatment of diseases dependent on metabolic pathways involving Syk, and also to a method for identifying such molecules.
Inventors:
Dahlia batch, Piona
Martaneau, Pierre Emil Julis
View tray, Bruno
Martaneau, Pierre Emil Julis
View tray, Bruno
Application Number:
JP2011503472A
Publication Date:
June 23, 2011
Filing Date:
April 08, 2009
Export Citation:
Assignee:
Center National de la Recherche Scientific-Se en Ale S-
International Classes:
A61K31/167; A61K31/18; A61K31/196; A61K31/343; A61K31/351; A61K31/4015; A61K31/4025; A61K31/4035; A61K31/4155; A61K31/4162; A61K31/4178; A61K31/4196; A61K31/427; A61K31/435; A61K31/443; A61K31/4439; A61K31/445; A61K31/47; A61K31/4709; A61K31/4725; A61K31/473; A61K31/495; A61K31/502; A61K31/506; A61K31/517; A61K31/53; A61K31/5377; A61K31/553; A61P7/10; A61P11/02; A61P11/06; A61P27/14; A61P37/08; A61P43/00; C07D207/38; C07D209/38; C07D209/48; C07D211/14; C07D211/62; C07D215/22; C07D217/04; C07D219/06; C07D221/16; C07D233/86; C07D237/32; C07D237/34; C07D249/12; C07D257/04; C07D295/18; C07D295/22; C07D307/84; C07D401/06; C07D401/12; C07D403/06; C07D403/12; C07D405/04; C07D405/06; C07D405/14; C07D407/12; C07D409/04; C07D409/06; C07D409/14; C07D417/04; C07D417/06; C07D491/052; C07D498/04; C07K16/40; C12N5/071; C12N9/12
Domestic Patent References:
| JP2007534954A | 2007-11-29 | |||
| JP2005523238A | 2005-08-04 | |||
| JP2007534954A | 2007-11-29 |
Foreign References:
| WO2006066846A1 | 2006-06-29 | |||
| WO2008120725A1 | 2008-10-09 |
Other References:
JPN6013048695; Ｄａｕｖｉｌｌｉｅｒ，Ｓ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１６９, 2002, ｐ．２２７４-２２８３
JPN6013048696; Ｍａｚｕｃ，Ｅ． ａｔ ａｌ: Ｍｅｃｈａｎｉｓｍｓ ｏｆ ａｌｌｅｒｇｙ ａｎｄ ｃｌｉｎｉｃａｌ ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１２２， Ｎｏ．１, 200807, ｐ．１８８-１９４．ｅ３
JPN6013048695; Ｄａｕｖｉｌｌｉｅｒ，Ｓ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１６９, 2002, ｐ．２２７４-２２８３
JPN6013048696; Ｍａｚｕｃ，Ｅ． ａｔ ａｌ: Ｍｅｃｈａｎｉｓｍｓ ｏｆ ａｌｌｅｒｇｙ ａｎｄ ｃｌｉｎｉｃａｌ ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１２２， Ｎｏ．１, 200807, ｐ．１８８-１９４．ｅ３
JPN6013048696; Ｍａｚｕｃ，Ｅ． ａｔ ａｌ: Ｍｅｃｈａｎｉｓｍｓ ｏｆ ａｌｌｅｒｇｙ ａｎｄ ｃｌｉｎｉｃａｌ ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１２２， Ｎｏ．１, 200807, ｐ．１８８-１９４．ｅ３
JPN6013048695; Ｄａｕｖｉｌｌｉｅｒ，Ｓ． ｅｔ ａｌ: Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１６９, 2002, ｐ．２２７４-２２８３
JPN6013048696; Ｍａｚｕｃ，Ｅ． ａｔ ａｌ: Ｍｅｃｈａｎｉｓｍｓ ｏｆ ａｌｌｅｒｇｙ ａｎｄ ｃｌｉｎｉｃａｌ ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１２２， Ｎｏ．１, 200807, ｐ．１８８-１９４．ｅ３
Attorney, Agent or Firm:
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa