Title:
安定化核酸ダーククエンチャー-フルオロフォアプローブ
Document Type and Number:
Japanese Patent JP2011519356
Kind Code:
A
Abstract:
The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex, or higher order aggregation (e.g. hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g. intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g. alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.
Inventors:
Cook, Ronald, M.
Lutre, Matt
Lutre, Matt
Application Number:
JP2011503151A
Publication Date:
July 07, 2011
Filing Date:
April 01, 2009
Export Citation:
Assignee:
Biosearch Technologies, Inc.
International Classes:
C07H19/073; C07F9/64; C07F9/6558; C07H19/10; C12N15/09; C12Q1/68
Foreign References:
| US7160996B1 | 2007-01-09 | |||
| WO2006049297A1 | 2006-05-11 | |||
| US0006003A | 1849-01-09 | |||
| US7160996B1 | 2007-01-09 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Toshifumi Onuki