Title:
2 ́-シアノ-2 ́-デオキシ-N4-パルミトイル-1-ベータ-D-アラビノフラノシルシトシンの合成に有用な中間体の調製
Document Type and Number:
Japanese Patent JP2011519907
Kind Code:
A
Abstract:
The present invention relates to a process for preparing a compound of formula 682-4, said process comprising the steps of: (i) converting a compound of formula 682-1 into a compound of formula 682-2'; (ii) converting said compound of formula 682-2' into a compound of formula 682-3; and (iii) converting said compound of formula 682-3 into a compound of formula 682-4. Further aspects of the invention relate to the use of the above process in the preparation of 2'-cyano-2'-deoxy-N 4 -palmitoyl-1-²-D-arabmofuranosylcytosine, a pyrimidine nucleoside which is therapeutically useful in the treatment and/or prevention of cancer.
Inventors:
Wood Gavin Jeffery
Westwood robert
Westwood robert
Application Number:
JP2011507983A
Publication Date:
July 14, 2011
Filing Date:
May 08, 2009
Export Citation:
Assignee:
Cyclacel Limited
International Classes:
C07H19/073
Domestic Patent References:
| JPH05194497A | 1993-08-03 | |||
| JPH0753586A | 1995-02-28 | |||
| JP2002308895A | 2002-10-23 | |||
| JP2002308895A | 2002-10-23 | |||
| JPH05194497A | 1993-08-03 | |||
| JPH0753586A | 1995-02-28 |
Attorney, Agent or Firm:
Masaki Hirota