Title:
置換キナゾリン
Document Type and Number:
Japanese Patent JP2011520865
Kind Code:
A
Abstract:
This invention relates to the discovery of substituted analogues of the selective platelet lowering agent anagrelide with reduced potential for cardiovascular side-effects which should lead to improved patient compliance and safety in the treatment of myeloproliferative diseases. More specifically, the present invention relates to certain imidazoquinazoline derivatives which have the general formula shown below wherein the substituents have the meanings defined in claim 1: and which have utility as platelet lowering agents in humans. The compounds of the present invention function by inhibiting megakaryocytopoeisis and hence the formation of blood platelets.
Inventors:
Golding, Bernard
Franklin, Richard
Franklin, Richard
Application Number:
JP2011509019A
Publication Date:
July 21, 2011
Filing Date:
May 13, 2009
Export Citation:
Assignee:
Shire LRC
International Classes:
C07D471/04; A61K31/4745; A61P7/00; A61P7/02; A61P35/02
Domestic Patent References:
| JPH0363277A | 1991-03-19 | |||
| JPS5170797A | 1976-06-18 | |||
| JPS5441894A | 1979-04-03 | |||
| JPS567786A | 1981-01-27 | |||
| JPS59155383A | 1984-09-04 | |||
| JPH09500108A | 1997-01-07 | |||
| JP2008509162A | 2008-03-27 |
Foreign References:
| US3974165A | 1976-08-10 | |||
| US3932407A | 1976-01-13 | |||
| US4593029A | 1986-06-03 | |||
| US4670434A | 1987-06-02 |
Other References:
JPN6013055953; Ｊ． Ｍｅｄ． Ｃｈｅｍ． ３１, 1988, ２１３６-２１４５
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori