Title:
リゾホスファチジン酸及びアデニリルシクラーゼの抑制剤を有効成分として含有する細胞老化調節用組成物
Document Type and Number:
Japanese Patent JP2011520872
Kind Code:
A
Abstract:
The present invention relates to the molecular mechanism inducing cell proliferation in aged human fibroblasts by inhibiting AMPK using LPA and AC inhibitor. Particularly, the present invention relates to a composition comprising LPA and ACI as active ingredients and the invention proves with the said composition that LPA and ACI regulate different phosphorylation of AMPKα and thus inactivate p53 and induce senescent cell proliferation. This results support the fact that AMPK signal transduction plays an important role in cell proliferation of senescent cells.
Inventors:
Park, San Chul
Yo, Lee Ju
Rim, The Hong
Yo, Lee Ju
Rim, The Hong
Application Number:
JP2011509389A
Publication Date:
July 21, 2011
Filing Date:
May 14, 2008
Export Citation:
Assignee:
Protherapeutics INC.
International Classes:
A61K31/661; A61K31/395; A61K31/52; A61K31/7076; A61K45/00; A61P43/00
Foreign References:
| US20060099568A1 | 2006-05-11 |
Attorney, Agent or Firm:
Kurata Masatoshi
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa
Satoshi Kono
Makoto Nakamura
Yoshihiro Fukuhara
Takashi Mine
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Katsu Sunagawa