Title:
ケモカイン受容体活性のクロメンモジュレーター
Document Type and Number:
Japanese Patent JP2011528359
Kind Code:
A
Abstract:
The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W1, W2, W3, Y, Z, R2, R3, R3′ and R4, are defined in the specification. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
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Inventors:
Douglas G Butt
Application Number:
JP2011518828A
Publication Date:
November 17, 2011
Filing Date:
July 14, 2009
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D311/60; A61K31/352; A61K31/4433; A61K31/4709; A61P1/04; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P37/04; A61P37/08; A61P43/00; C07D311/92; C07D405/04
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka