Title:
直径10~20μmのマイクロスフェアを含む非経口組成物
Document Type and Number:
Japanese Patent JP2011529946
Kind Code:
A
Abstract:
The present invention relates to pharmaceutical formulations suitable for targeting particular tissue and/or organ(s) with a formulated active ingredient, for example when administered upstream of the target organ or tissue, and to use of the same in treatment, methods of treatment administering the same and methods of preparing the formulations. The pharmaceutical formulations of the invention are for parenteral administration to a target tissue and comprise particles containing an active ingredient, and a biodegradable excipient, wherein 90% or more of the particles have a diameter of between 10 and 20 microns and the formulation is substantially free of particles with a diameter greater than 50 microns and less than 5 microns, such that where the formulation is administered upstream of the target tissue the ability of the active to pass through the target tissue and pass into systemic circulation is restricted.
Inventors:
Nadal Hinard, Bernardo
Application Number:
JP2011521575A
Publication Date:
December 15, 2011
Filing Date:
August 05, 2009
Export Citation:
Assignee:
Core Therapy SLU
International Classes:
A61K9/14; A61K38/00; A61K38/04; A61K38/22; A61K38/27; A61P9/10
Domestic Patent References:
| JPH10510527A | 1998-10-13 | |||
| JP2001524096A | 2001-11-27 | |||
| JP2005104910A | 2005-04-21 | |||
| JP2005534651A | 2005-11-17 |
Foreign References:
| WO2003059375A1 | 2003-07-24 | |||
| WO2005094888A1 | 2005-10-13 | |||
| WO2007059010A2 | 2007-05-24 | |||
| WO2006117422A2 | 2006-11-09 | |||
| WO2008047863A1 | 2008-04-24 | |||
| WO2003059375A1 | 2003-07-24 | |||
| WO2005094888A1 | 2005-10-13 |
Other References:
JPN6013057794; 医学のあゆみ 第２１７巻 第５号 ｐ．４０９-４１３ , 20060429
CSNC201000324020; 医学のあゆみ 第２１７巻 第５号 ｐ．４０９-４１３ , 20060429
CSNC201000324020; 医学のあゆみ 第２１７巻 第５号 ｐ．４０９-４１３ , 20060429
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka