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Title:
放射標識アネキシン
Document Type and Number:
Japanese Patent JP2012501322
Kind Code:
A
Abstract:
A radiolabeled annexin comprising at least 2 up to 20 histidine residues at its N-terminus is disclosed. At least two of said histidine residues are adjacent or separated by no more than one other amino acid. The radiolabeled annexin is a stable complex with a radionuclide such as technetium 99m. The radiolabeled annexin can be used in a method of imaging cell death in a nucleated cell within a region of a mammalian subject in vivo.

Inventors:
レウテリンクスペルゲル、クリスティアーン・ペーテル・マリア
モーネン、ペーテル・ヨゼフ・ヤコブス
Application Number:
JP2011524925A
Publication Date:
January 19, 2012
Filing Date:
August 26, 2009
Export Citation:
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Assignee:
MosaMedix B.V.
International Classes:
C07K14/47; A61K51/00; C07B59/00
Domestic Patent References:
JP2007525653A2007-09-06
JP2007525653A2007-09-06
Foreign References:
WO2006003488A22006-01-12
WO2006003488A22006-01-12
Other References:
JPN6014004788; Bioconjugate Chemistry vol.11, 2000, p.918-925
JPN5011012434; WAIBEL ROBERT: 'STABLE ONE-STEP TECHNETIUM-99M LABELING OF HIS-TAGGED RECOMBINANT PROTEINS 以下備考' NATURE BIOTECHNOLOGY V17 N9, 199909, P897-901
JPN6014004788; Bioconjugate Chemistry vol.11, 2000, p.918-925
JPN5011012434; WAIBEL ROBERT: 'STABLE ONE-STEP TECHNETIUM-99M LABELING OF HIS-TAGGED RECOMBINANT PROTEINS 以下備考' NATURE BIOTECHNOLOGY V17 N9, 199909, P897-901
Attorney, Agent or Firm:
蔵田 昌俊
高倉 成男
河野 哲
中村 誠
福原 淑弘
峰 隆司
白根 俊郎
村松 貞男
野河 信久
幸長 保次郎
河野 直樹
砂川 克
井関 守三
佐藤 立志
岡田 貴志
堀内 美保子
竹内 将訓