Title:
EP4受容体アンタゴニストとしてのベータ-カルボリンスルホニルウレア誘導体
Document Type and Number:
Japanese Patent JP2012503605
Kind Code:
A
Abstract:
The invention is directed to β-carboline sulphonylurea derivatives as EP4 receptor antagonists useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, inflammation, osteoarthritis, and rheumatoid arthritis. Pharmaceutical compositions and methods of use are also included.
Inventors:
Belle serette, curl
Boyd, Michael
Birch, the aison
Deux Flaine, Claude
Huaran, Lily
Han, Young Shin
Stuyulino, Claudio Ef
Boyd, Michael
Birch, the aison
Deux Flaine, Claude
Huaran, Lily
Han, Young Shin
Stuyulino, Claudio Ef
Application Number:
JP2011528146A
Publication Date:
February 09, 2012
Filing Date:
September 22, 2009
Export Citation:
Assignee:
MERCK CANADA INC.
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61P1/02; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/00; A61P7/06; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P13/12; A61P15/00; A61P15/10; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/14; A61P25/16; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P27/02; A61P27/06; A61P29/00; A61P31/12; A61P31/16; A61P35/00; A61P35/02; A61P37/00; A61P43/00
Domestic Patent References:
| JP2005518413A | 2005-06-23 | |||
| JP2007277255A | 2007-10-25 | |||
| JP2004504380A | 2004-02-12 | |||
| JP2010522218A | 2010-07-01 |
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Yasufumi Shiroyama