Title:
エタノールの影響に対する耐性を有するpH依存の制御放出の医薬オピオイド組成物
Document Type and Number:
Japanese Patent JP2012503608
Kind Code:
A
Abstract:
The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising a core, and an opioid, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0, characterized in that the coating layer further comprises 110 to 250% by weight of a non-porous inert lubricant, 1 to 35% by weight of a neutral cellulosic compound and 1 to 25% by weight of an emulsifier, each calculated on dry weight of the polymer mixture.
Inventors:
Hans Behr
Thomas fuast
Gearhart Renner
Michael Gottschalk
Thomas fuast
Gearhart Renner
Michael Gottschalk
Application Number:
JP2011528191A
Publication Date:
February 09, 2012
Filing Date:
September 24, 2008
Export Citation:
Assignee:
Evonik Roehm GmbH
International Classes:
A61K9/50; A61K9/14; A61K9/20; A61K9/48; A61K31/485; A61K47/02; A61K47/12; A61K47/32; A61K47/34; A61K47/38; A61P25/04
Domestic Patent References:
| JP2008528534A | 2008-07-31 | |||
| JP2004196829A | 2004-07-15 | |||
| JP2010539197A | 2010-12-16 |
Foreign References:
| WO2006125483A1 | 2006-11-30 |
Attorney, Agent or Firm:
Takuya Kuno
Toshio Yano
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Ryoichi Shino
Einzel Felix-Reinhard
Toshio Yano
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Ryoichi Shino
Einzel Felix-Reinhard