Title:
インターロイキン-15活性のペプチドアンタゴニスト
Document Type and Number:
Japanese Patent JP2012503976
Kind Code:
A
Abstract:
The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor ± (TNF±) induction and the expression of IL-8 and IL-6 by the IL-15 receptor ± subunit (IL-15R±), all these effects mediated by the binding of the peptide to the IL-15R±. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15R± is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer.
Inventors:
Santos Savio, Alicia
Reyes Acosta, Osvaldo
Jeronimo Perez, Heidi
Galei Perez, Hilda, Elisa
Rodriguez Alvarez, Uni
Gillen Nieto, Herald, Enrique
Reyes Acosta, Osvaldo
Jeronimo Perez, Heidi
Galei Perez, Hilda, Elisa
Rodriguez Alvarez, Uni
Gillen Nieto, Herald, Enrique
Application Number:
JP2011528178A
Publication Date:
February 16, 2012
Filing Date:
September 30, 2009
Export Citation:
Assignee:
Centro in the Any Area Energy Biotechnology
International Classes:
A61K38/00; C12N15/09; A61P1/04; A61P15/00; A61P17/04; A61P19/02; A61P35/00; A61P43/00; C07K7/06; C07K14/54
Domestic Patent References:
| JP2008512994A | 2008-05-01 | |||
| JP2006507229A | 2006-03-02 | |||
| JP2003146997A | 2003-05-21 | |||
| JPH11507082A | 1999-06-22 | |||
| JP2007528726A | 2007-10-18 |
Other References:
CYTOKINE GROWTH FACTOR REV., 2006, VOL. 17, NO. 4, PP. 259-280, JPN6013061646, ISSN: 0002705068
J.BIOL.CHEM.,2004 JUN 4,279(23),P.24313-22, JPN6011006378, ISSN: 0002705069
J.BIOL.CHEM.,2004 JUN 4,279(23),P.24313-22, JPN6011006378, ISSN: 0002705069
Attorney, Agent or Firm:
Asamura patent office
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Katsuhiko Shimomura
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Katsuhiko Shimomura