Title:
ステアロイルコエンザイムAデルタ-9デサチュラーゼの阻害剤としての芳香族複素環化合物
Document Type and Number:
Japanese Patent JP2012504557
Kind Code:
A
Abstract:
Heteroaromatic compounds of structural formula (I) are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis.
Inventors:
Leclerc, Jean-Philippe
Lee, Chun, Shin
Ramtor, Eman, Kay.
Lee, Chun, Shin
Ramtor, Eman, Kay.
Application Number:
JP2011529427A
Publication Date:
February 23, 2012
Filing Date:
September 30, 2009
Export Citation:
Assignee:
MERCK CANADA INC.
International Classes:
C07D417/04; A61K31/428; A61K31/437; A61K31/4985; A61K31/519; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P43/00; C07D471/04; C07D487/04; C07D513/04
Attorney, Agent or Firm:
Kenji Ando