RGD含有ペプチド模倣体及びその使用

Japanese Patent JP2012506419

A

The invention provides RGD-containing cyclic peptidomimetics; conjugates of said peptidomimetics and a moiety of a payload selected from fluorescent probes, photosensitizers, chelating agents, or cytotoxic agents; and pharmaceutical compositions comprising these conjugates. The conjugates of the invention are useful both for diagnostic purposes and treatment of various diseases, disorders and conditions. More specifically, conjugates comprising fluorescent probes can be used for diagnostic purposes, e.g., visualization of organs and tissues, and diagnosis of tumors; conjugates comprising photosensitizers can be used for photodynamic therapy of both tumors and nonneoplastic tissues; conjugates comprising chelating agents can be used in radioimaging or radiotherapy; and conjugates comprising cytotoxic agents can be used for targeted chemotherapy.

JPH10226652	DRUG FOR PREVENTION AND TREATMENT OF DISEASE BY USING APICIDIN
WO/2011/055247	A SYNTHETIC CYCLIC DIPEPTIDE AND A PROCESS THEREOF
JPH06157588	CELL ADHESION ACTIVE NEW PEPTIDE DERIVATIVE

Ellen, Delon
Yecheskell, Tamar
Saritra, Joseph
Koudi Nova, Natalia

JP2011532768A

March 15, 2012

October 22, 2009

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STEBA BIOTECH N.V.

C07K5/12; A61K31/409; A61K38/00; A61K41/00; A61K47/48; A61K49/00; A61P3/04; A61P27/02; A61P35/00; A61P43/00

JP2001501600A

2001-02-06

WO2008023378A1	2008-02-28
WO1995028426A2	1995-10-26

JPN6014014233; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ． Ｖｏｌ．９９，　Ｎｏ．３, 20020205, ｐ．１２４７-１２５２
JPN6014014234; Ｍｏｌ．　Ｐｈａｒｍ． Ｖｏｌ．３，　Ｎｏ．５, 200610, ｐ．４７２-４８７

Asamura patent office
Hideto Asamura
Hajime Asamura
Shinichi Inoue
Naganuma Akio
Yukihiro Ikeda
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe
Katsuhiko Shimomura

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