Title:
アリールピペラジンおよびアルファ2Cアンタゴニストとしてのそれらの使用
Document Type and Number:
Japanese Patent JP2012509302
Kind Code:
A
Abstract:
Compounds of formula (I), wherein X, Z, A, B, D, E, R1-R4 and m are as defined in the claims, exhibit alpha2C antagonistic activity and are thus useful as alpha2 antagonists.
Inventors:
Dinbelle, David
Holm, Patrick
Torbane, Alto
Vorfert, gerd
Holm, Patrick
Torbane, Alto
Vorfert, gerd
Application Number:
JP2011536911A
Publication Date:
April 19, 2012
Filing Date:
November 20, 2009
Export Citation:
Assignee:
Orion Corporation
International Classes:
C07D405/06; A61K31/496; A61K31/551; A61K51/00; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; C07D405/14; C07D411/06
Domestic Patent References:
| JPS5515456A | 1980-02-02 |
Foreign References:
| WO2009013390A1 | 2009-01-29 | |||
| US4788290A | 1988-11-29 | |||
| US3362956A | 1968-01-09 | |||
| WO2003029239A1 | 2003-04-10 |
Other References:
JPN5012003788; ＰＡＴＥＬ Ｓ Ｄ: 'ＩＤＥＮＴＩＦＩＣＡＴＩＯＮ ＡＮＤ ＳＡＲ ＡＲＯＵＮＤ Ｎ-｛２-［４-（２，３-ＤＩＨＹＤＲＯ-ＢＥＮＺＯ［１，４］ＤＩＯＸＩＮ-２-ＹＬＭＥＴＨＹＬ）- 以下備考' ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖ１８ Ｎ２０, 20081015, Ｐ５６８９-５６９３, ＰＥＲＧＡＭＯＮ， ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ
JPN5012003789; ＳＷＡＩＮ Ａ Ｐ: 'ＡＤＲＥＮＥＲＧＩＣ ＢＬＯＣＫＩＮＧ ＡＧＥＮＴＳ． ＩＩ． ＰＩＰＥＲＡＺＩＮＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ Ｖ７６, 195410, Ｐ５０９１-５０９３, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN5012003790; ＳＴＥＥＮ ＶＡＮ Ｂ Ｊ: 'ＳＴＲＵＣＴＵＲＥ-ＡＦＦＩＮＩＴＹ ＲＥＬＡＴＩＯＮＳＨＩＰ ＳＴＵＤＩＥＳ ＯＮ ５-ＨＴ１Ａ ＲＥＣＥＰＴＯＲ ＬＩＧＡＮＤＳ． 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ３７ Ｎ１７, 19940819, Ｐ２７６１-２７７３, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN5012003789; ＳＷＡＩＮ Ａ Ｐ: 'ＡＤＲＥＮＥＲＧＩＣ ＢＬＯＣＫＩＮＧ ＡＧＥＮＴＳ． ＩＩ． ＰＩＰＥＲＡＺＩＮＥＳ' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ Ｖ７６, 195410, Ｐ５０９１-５０９３, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN5012003790; ＳＴＥＥＮ ＶＡＮ Ｂ Ｊ: 'ＳＴＲＵＣＴＵＲＥ-ＡＦＦＩＮＩＴＹ ＲＥＬＡＴＩＯＮＳＨＩＰ ＳＴＵＤＩＥＳ ＯＮ ５-ＨＴ１Ａ ＲＥＣＥＰＴＯＲ ＬＩＧＡＮＤＳ． 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ３７ Ｎ１７, 19940819, Ｐ２７６１-２７７３, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
Attorney, Agent or Firm:
Kawamura Taku
Yousuke Fujimori
Seiji Tani
Yousuke Fujimori
Seiji Tani